UniProt P25105
Platelet-activating factor receptor (P25105)
Platelet-activating factor receptor (UniProt P25105): 3 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25105
- Protein
- Platelet-activating factor receptor
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 4 · 1 record with a druggable one
Structures
4 records of P25105 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZKP | Crystal structure of the human platelet-activating factor receptor in complex with sr 27417 | x-ray diffraction | A | 9ER, FMN | — |
| 5ZKQ | Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | x-ray diffraction | A, B | 9EU, ZN, SO4 | — |
| 5ZKQ | Crystal structure of the human platelet-activating factor receptor in complex with abt-491 | x-ray diffraction | A, B | 9EU, ZN, SO4 | — |
| P25105 | AlphaFold monomer V2.0 prediction for platelet-activating factor receptor (P25105) | predicted | A | — | 4 (best 0.80) |
Ligands
- 9EU · 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- ZN · Zinc ion · in 2 records
- 9ER · N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine · in 1 record
- FMN · Flavin mononucleotide · in 1 record
Experiment against prediction
- 5ZKP chain A against the predicted model P00323: TM-score 0.34, RMSD 0.50 Å
- 5ZKQ chain A against the predicted model P25105: TM-score 0.96, RMSD 1.55 Å
- 5ZKQ chain A against the predicted model P25105: TM-score 0.96, RMSD 1.55 Å
- 5ZKQ chain B against the predicted model P25105: TM-score 0.68, RMSD 2.12 Å
- 5ZKQ chain B against the predicted model P25105: TM-score 0.68, RMSD 2.12 Å
- 5ZKP chain A against the predicted model P25105: TM-score 0.59, RMSD 2.47 Å
Elsewhere
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