UniProt P25092
Guanylyl cyclase C (P25092)
Guanylyl cyclase C (UniProt P25092), EC 4.6.1.2: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25092
- Protein
- Guanylyl cyclase C
- EC
- 4.6.1.2
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 2 records with a druggable one
Structures
4 records of P25092 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8FX4 | GC-C-Hsp90-Cdc37 regulatory complex | electron microscopy | D | — | 7 (best 0.86) |
| 8GHO | GUCY2C-peptide bound to anti-GUCY2C-scFv antibody | x-ray diffraction | C, G | — | — |
| 8GHP | GUCY2C-ECD bound to anti-GUCY2C-scFv antibody | x-ray diffraction | A | NAG | 4 (best 0.78) |
| P25092 | AlphaFold monomer V2.0 prediction for heat-stable enterotoxin receptor (P25092) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 8GHP chain A against the predicted model P25092: TM-score 0.94, RMSD 1.75 Å
- 8FX4 chain D against the predicted model P25092: TM-score 0.83, RMSD 2.87 Å
- 8GHO chain G against the predicted model P25092: TM-score 0.70, RMSD 1.48 Å
- 8GHO chain C against the predicted model P25092: TM-score 0.56, RMSD 1.63 Å
Elsewhere
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