UniProt P25046

Mediator of RNA polymerase II transcription subunit 19 (P25046)

Mediator of RNA polymerase II transcription subunit 19 (UniProt P25046): 6 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P25046
Protein: Mediator of RNA polymerase II transcription subunit 19
Experimental structures: 6
Predicted models: 1
Pockets: 8 · 6 records with a druggable one

Structures

7 records of P25046 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5OQM	Structure of yeast transcription pre-initiation complex with tfiih and core mediator	electron microscopy	m	—	1 (best 0.79)
5OQM	Structure of yeast transcription pre-initiation complex with tfiih and core mediator	electron microscopy	m	—	1 (best 0.79)
7UI9	Core Mediator-PICearly (Copy A)	electron microscopy	s	—	1 (best 0.84)
7UIF	Mediator-PIC Early (Core B)	electron microscopy	s	—	1 (best 0.85)
7UIG	Mediator-PIC Early (Mediator A)	electron microscopy	s	—	2 (best 0.84)
7UIO	Mediator-PIC Early (Composite Model)	electron microscopy	As, Bs	—	1 (best 0.81)
P25046	AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 19…	predicted	A	—	1 (best 0.27)

Experiment against prediction

7UIG chain s against the predicted model P25046: TM-score 0.74, RMSD 2.03 Å
7UI9 chain s against the predicted model P25046: TM-score 0.74, RMSD 2.03 Å
7UIF chain s against the predicted model P25046: TM-score 0.74, RMSD 2.03 Å
7UIO chain As against the predicted model P25046: TM-score 0.74, RMSD 2.04 Å
5OQM chain m against the predicted model P25046: TM-score 0.60, RMSD 3.09 Å
5OQM chain m against the predicted model P25046: TM-score 0.60, RMSD 3.09 Å

Elsewhere

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