UniProt P24928
DNA-directed RNA polymerase II subunit RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (UniProt P24928), EC 2.7.7.48, 2.7.7.6: 35 experimental structures on GenesisL1, 2 ligands bound, 92 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P24928
- Protein
- DNA-directed RNA polymerase II subunit RPB1
- EC
- 2.7.7.48, 2.7.7.6
- Experimental structures
- 35
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 92 · 8 records with a druggable one
Structures
35 records of P24928 in the MolNFT archive: 35 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GHQ | CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II | x-ray diffraction | C, D | — | — |
| 2GHQ | Ctd-specific phosphatase SCP1 in complex with peptide C-terminal domain of RNA polymerase II | x-ray diffraction | C, D | — | — |
| 2GHT | CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II | x-ray diffraction | C, D | — | — |
| 2GHT | Ctd-specific phosphatase SCP1 in complex with peptide from C-terminal domain of RNA polymerase II | x-ray diffraction | C, D | — | — |
| 2LTO | TDRD3 complex | solution nmr | B | — | — |
| 2LTO | TDRD3 complex | solution nmr | B | — | — |
| 4JXT | CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD | x-ray diffraction | B | — | — |
| 4JXT | Cid of human RPRD1A in complex with a phosphorylated peptide from RPB1-ctd | x-ray diffraction | B | — | — |
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | A | MG, ZN | 13 (best 0.88) |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | A | — | — |
| 5IY7 | Human holo-PIC in the open state | electron microscopy | A | MG, ZN | 12 (best 0.88) |
| 5IY7 | Human holo-pic in the open state | electron microscopy | A | — | — |
| 5IY8 | Human holo-PIC in the initial transcribing state | electron microscopy | A | MG, ZN | 13 (best 0.89) |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | A | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | A | MG, ZN | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | A | — | — |
| 5IYA | Human core-PIC in the closed state | electron microscopy | A | MG, ZN | — |
| 5IYA | Human core-pic in the closed state | electron microscopy | A | — | — |
| 5IYB | Human core-PIC in the open state | electron microscopy | A | MG, ZN | 15 (best 0.87) |
| 5IYB | Human core-pic in the open state | electron microscopy | A | — | — |
| 5IYC | Human core-PIC in the initial transcribing state | electron microscopy | A | MG, ZN | 12 (best 0.91) |
| 5IYC | Human core-pic in the initial transcribing state | electron microscopy | A | — | — |
| 5IYD | Human core-PIC in the initial transcribing state (no IIS) | electron microscopy | A | MG, ZN | — |
| 5IYD | Human core-pic in the initial transcribing state (no iis) | electron microscopy | A | — | — |
| 6DRD | RNA Pol II(G) | electron microscopy | A | — | 12 (best 0.87) |
| 6DRD | RNA pol II(G) | electron microscopy | A | — | — |
| 6G0R | Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A… | x-ray diffraction | C | — | — |
| 6G0R | Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A… | x-ray diffraction | C | — | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | A | MG, ZN | — |
| 6XRE | Structure of the P53/RNA polymerase II assembly | electron microscopy | A | MG, ZN | — |
| 7EGB | TFIID-based holo PIC on SCP promoter | electron microscopy | o | ZN, MG | 4 (best 0.88) |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | o | ZN, MG | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | 1 | MG, ZN | 11 (best 0.87) |
| 9B9L | RPRD1B C-terminal interacting domain bound to a pThr4 CTD peptide | x-ray diffraction | C | — | — |
| P24928 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P24928) | — | — | — |
Ligands
Elsewhere
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