UniProt P24864
G1/S-specific cyclin-E1 (P24864)
G1/S-specific cyclin-E1 (UniProt P24864): 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P24864
- Protein
- G1/S-specific cyclin-E1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 6 · 2 records with a druggable one
Structures
9 records of P24864 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W98 | The structural basis of CDK2 activation by cyclin E | x-ray diffraction | B | — | — |
| 1W98 | The structural basis of CDK2 activation by cyclin E | x-ray diffraction | B | — | — |
| 5L2W | The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib. | x-ray diffraction | B | — | — |
| 5L2W | The X-ray co-crystal structure of human CDK2/CYCLINE and dinaciclib. | x-ray diffraction | B | — | — |
| 7KJS | Crystal structure of CDK2/CYCLIN E in complex with pf-06873600 | x-ray diffraction | B | — | — |
| 7XQK | The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus. | x-ray diffraction | B | SO4 | — |
| 8H4R | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | x-ray diffraction | B | SO4 | 3 (best 0.79) |
| 8VQ3 | CDK2-CyclinE1 in complex with allosteric inhibitor I-198. | x-ray diffraction | B | A1AC4 | 3 (best 0.82) |
| P24864 | AlphaFold monomer V2.0 prediction for G1/S-specific cyclin-E1 (P24864) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1W98 chain B against the predicted model P24864: TM-score 1.00, RMSD 0.32 Å
- 1W98 chain B against the predicted model P24864: TM-score 1.00, RMSD 0.32 Å
- 5L2W chain B against the predicted model P24864: TM-score 1.00, RMSD 0.39 Å
- 5L2W chain B against the predicted model P24864: TM-score 1.00, RMSD 0.39 Å
- 7XQK chain B against the predicted model P24864: TM-score 1.00, RMSD 0.42 Å
- 7KJS chain B against the predicted model P24864: TM-score 1.00, RMSD 0.41 Å
- 8H4R chain B against the predicted model P24864: TM-score 0.99, RMSD 0.58 Å
- 8VQ3 chain B against the predicted model P24864: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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