UniProt P24462
Cytochrome P450 3A7 (P24462)
Cytochrome P450 3A7 (UniProt P24462), EC 1.14.14.1: 1 experimental structure and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P24462
- Protein
- Cytochrome P450 3A7
- EC
- 1.14.14.1
- Experimental structures
- 1
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 1 record with a druggable one
Structures
2 records of P24462 in the MolNFT archive: 1 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GK3 | Cytochrome P450 3A7 in complex with Dehydroepiandrosterone sulfate | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | HEM, ZWY | 20 (best 0.88) |
| P24462 | AlphaFold monomer V2.0 prediction for cytochrome P450 3A7 (P24462) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8GK3 chain L against the predicted model P24462: TM-score 0.96, RMSD 1.63 Å
- 8GK3 chain G against the predicted model P24462: TM-score 0.96, RMSD 1.77 Å
- 8GK3 chain B against the predicted model P24462: TM-score 0.95, RMSD 1.77 Å
- 8GK3 chain F against the predicted model P24462: TM-score 0.95, RMSD 1.84 Å
- 8GK3 chain K against the predicted model P24462: TM-score 0.95, RMSD 1.86 Å
- 8GK3 chain D against the predicted model P24462: TM-score 0.95, RMSD 1.88 Å
- 8GK3 chain J against the predicted model P24462: TM-score 0.95, RMSD 1.91 Å
- 8GK3 chain A against the predicted model P24462: TM-score 0.95, RMSD 2.02 Å
- 8GK3 chain E against the predicted model P24462: TM-score 0.95, RMSD 1.92 Å
- 8GK3 chain H against the predicted model P24462: TM-score 0.95, RMSD 1.96 Å
Elsewhere
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