UniProt P23886
ATP-binding/permease protein CydC (P23886)
ATP-binding/permease protein CydC (UniProt P23886): 15 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 162 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23886
- Protein
- ATP-binding/permease protein CydC
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 162 · 14 records with a druggable one
Structures
16 records of P23886 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ZD5 | IF(apo/as isolated) conformation of CydDC (Dataset-1) | electron microscopy | C | — | 14 (best 0.82) |
| 7ZDA | IF(apo/asym) conformation of CydDC in ADP+Pi(CydC)/ATP(CydD) bound state (Dataset-2) | electron microscopy | C | MG, ADP, PO3 | 10 (best 0.84) |
| 7ZDB | IF(heme/bound) conformation of CydDC in ADP+Pi(CydC)/ATP(CydD) bound state (Dataset-2) | electron microscopy | C | HEB, MG, ADP, PO3 | 10 (best 0.84) |
| 7ZDC | IF(heme/confined) conformation of CydDC in ADP(CydD) bound state (Dataset-3) | electron microscopy | C | HEB | 10 (best 0.83) |
| 7ZDE | IF(apo/as isolated) conformation of CydDC in AMP-PNP(CydD) bound state (Dataset-4) | electron microscopy | C | — | 13 (best 0.81) |
| 7ZDF | IF(heme/confined) conformation of CydDC in AMP-PNP(CydD) bound state (Dataset-4) | electron microscopy | C | ISW | 7 (best 0.87) |
| 7ZDG | IF(heme/confined) conformation of CydDC (Dataset-5) | electron microscopy | C | HEB | 11 (best 0.87) |
| 7ZDK | IF(apo/asym) conformation of CydDC in AMP-PNP(CydC)/AMP-PNP(CydD) bound state (Dataset-8) | electron microscopy | C | MG, ANP | 13 (best 0.83) |
| 7ZDL | IF(heme/coordinated) conformation of CydDC in AMP-PNP(CydC)/AMP-PNP(CydD) bound state (Dataset-8) | electron microscopy | C | HEB, MG, ANP | — |
| 7ZDR | IF(apo/as isolated) conformation of CydDC mutant (H85A.C) in AMP-PNP(CydD) bound state (Dataset-16) | electron microscopy | C | — | 14 (best 0.82) |
| 7ZDS | IF(apo/as isolated) conformation of CydDC mutant (E500Q.C) (Dataset-18) | electron microscopy | C | — | 11 (best 0.81) |
| 7ZDT | Occ(apo/return) conformation of CydDC mutant (E500Q.C) in ATP(CydC) bound state (Dataset-18) | electron microscopy | C | MG, ATP | 10 (best 0.88) |
| 7ZDU | Occ(apo/return) conformation of CydDC mutant (E500Q.C) in ATP(CydC)/ATP(CydD) bound state… | electron microscopy | C | MG, ATP | 13 (best 0.84) |
| 7ZDW | IF(heme/confined) conformation of CydDC mutant (E500Q.C) in AMP-PNP(CydD) bound state (Dataset-22) | electron microscopy | C | HEB | 13 (best 0.81) |
| 7ZEC | IF(heme/confined) conformation of CydDC in ATP(CydD) bound state (Dataset-15) | electron microscopy | C | HEB | 13 (best 0.87) |
| P23886 | AlphaFold monomer V2.0 prediction for ATP-BINDING/PERMEASE protein cydc (P23886) | predicted | A | — | — |
Ligands
- HEB · Heme B/C · in 6 records
- MG · Magnesium ion · in 6 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- PO3 · Phosphite ion · in 2 records
- ISW · {3,3'-[(9S)-8,13-diethenyl-3,7,12,17-tetramethyl-9,10-dihydroporphyrin-2,18-diyl-kappa~4~n~21~,n~22~,n~23~, n~24~]dipropanoato(2-)}iron · in 1 record
Experiment against prediction
- 7ZDU chain C against the predicted model P23886: TM-score 0.95, RMSD 2.07 Å
- 7ZDT chain C against the predicted model P23886: TM-score 0.94, RMSD 2.11 Å
- 7ZDS chain C against the predicted model P23886: TM-score 0.90, RMSD 3.11 Å
- 7ZDK chain C against the predicted model P23886: TM-score 0.89, RMSD 3.33 Å
- 7ZDL chain C against the predicted model P23886: TM-score 0.89, RMSD 3.25 Å
- 7ZEC chain C against the predicted model P23886: TM-score 0.89, RMSD 3.15 Å
- 7ZDB chain C against the predicted model P23886: TM-score 0.88, RMSD 3.27 Å
- 7ZDC chain C against the predicted model P23886: TM-score 0.88, RMSD 3.17 Å
- 7ZDA chain C against the predicted model P23886: TM-score 0.88, RMSD 3.43 Å
- 7ZDG chain C against the predicted model P23886: TM-score 0.88, RMSD 3.35 Å
Elsewhere
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