UniProt P23677
Inositol-trisphosphate 3-kinase A (P23677)
Inositol-trisphosphate 3-kinase A (UniProt P23677), EC 2.7.1.127: 10 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P23677
- Protein
- Inositol-trisphosphate 3-kinase A
- EC
- 2.7.1.127
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 7 · 2 records with a druggable one
Structures
11 records of P23677 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W2C | Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3 | x-ray diffraction | A, B | — | — |
| 1W2C | Human inositol (1,4,5) trisphosphate 3-kinase complexed with MN2+/AMPPNP/INS(1,4,5)P3 | x-ray diffraction | A, B | — | — |
| 1W2D | Human Inositol (1,4,5)-trisphosphate 3-kinase complexed with Mn2+/ADP/Ins(1,3,4,5)P4 | x-ray diffraction | A, B | — | — |
| 1W2D | Human inositol (1,4,5)-trisphosphate 3-kinase complexed with MN2+/ADP/INS(1,3,4,5)P4 | x-ray diffraction | A, B | — | — |
| 1W2F | Human Inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine | x-ray diffraction | A, B | — | — |
| 1W2F | Human inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine | x-ray diffraction | A, B | — | — |
| 4UPU | Crystal structure of IP3 3-K calmodulin binding region in complex with Calmodulin | x-ray diffraction | B | — | — |
| 4UPU | Crystal structure of IP3 3-K calmodulin binding region in complex with calmodulin | x-ray diffraction | B | — | — |
| 8PP8 | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with… | x-ray diffraction | A, B | ANP, 3IA, MN, SO4 | 3 (best 0.69) |
| 8PPC | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with… | x-ray diffraction | A, B | 2KM, ATP, MN, SO4 | 4 (best 0.79) |
| P23677 | AlphaFold monomer V2.0 prediction for inositol-trisphosphate 3-kinase a (P23677) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1W2D chain A against the predicted model P23677: TM-score 1.00, RMSD 0.40 Å
- 1W2D chain A against the predicted model P23677: TM-score 1.00, RMSD 0.40 Å
- 1W2C chain A against the predicted model P23677: TM-score 0.99, RMSD 0.46 Å
- 1W2C chain A against the predicted model P23677: TM-score 0.99, RMSD 0.46 Å
- 1W2C chain B against the predicted model P23677: TM-score 0.99, RMSD 0.60 Å
- 1W2C chain B against the predicted model P23677: TM-score 0.99, RMSD 0.60 Å
- 1W2D chain B against the predicted model P23677: TM-score 0.99, RMSD 0.61 Å
- 1W2D chain B against the predicted model P23677: TM-score 0.99, RMSD 0.61 Å
- 8PP8 chain A against the predicted model P23677: TM-score 0.99, RMSD 0.73 Å
- 8PP8 chain B against the predicted model P23677: TM-score 0.99, RMSD 0.96 Å
Elsewhere
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