UniProt P23368
NAD-dependent malic enzyme, mitochondrial (P23368)
NAD-dependent malic enzyme, mitochondrial (UniProt P23368), EC 1.1.1.38: 28 experimental structures on GenesisL1, 4 ligands bound, 69 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P23368
- Protein
- NAD-dependent malic enzyme, mitochondrial
- EC
- 1.1.1.38
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 69 · 4 records with a druggable one
Structures
28 records of P23368 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DO8 | Crystal structure of a closed form of human mitochondrial NAD(P)+-dependent malic enzyme | x-ray diffraction | A, B, C, D | — | — |
| 1DO8 | Crystal structure of a closed form of human mitochondrial NAD(P)+- dependent malic enzyme | x-ray diffraction | A, B, C, D | — | — |
| 1EFK | Structure of human malic enzyme in complex with ketomalonate | x-ray diffraction | A, B, C, D | — | — |
| 1EFK | Structure of human malic enzyme in complex with ketomalonate | x-ray diffraction | A, B, C, D | — | — |
| 1EFL | Human malic enzyme in a quaternary complex with NAD, mg, and tartronate | x-ray diffraction | A, B, C, D | — | — |
| 1EFL | Human malic enzyme in a quaternary complex with NAD, mg, and tartronate | x-ray diffraction | A, B, C, D | — | — |
| 1GZ3 | Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP… | x-ray diffraction | A, B, C, D | — | — |
| 1GZ3 | Molecular mechanism for the regulation of human mitochondrial NAD(P)+- dependent malic enzyme by… | x-ray diffraction | A, B, C, D | — | — |
| 1GZ4 | molecular mechanism of the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP… | x-ray diffraction | A, B, C, D | — | — |
| 1GZ4 | Molecular mechanism of the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ2 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ2 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ3 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ3 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ4 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJ4 | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with… | x-ray diffraction | A, B, C, D | — | — |
| 1PJL | Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+ | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1PJL | Crystal structure of human M-NAD-me in ternary complex with NAD and LU3+ | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1QR6 | Human mitochondrial NAD(P)-dependent malic enzyme | x-ray diffraction | A, B | — | — |
| 1QR6 | Human mitochondrial NAD(P)-dependent malic enzyme | x-ray diffraction | A, B | — | — |
| 7BSJ | Crystal structure of human ME2 R484W | x-ray diffraction | A, B | NAD, MG, FUM, TTN | 15 (best 0.83) |
| 7BSJ | Crystal structure of human ME2 R484W | x-ray diffraction | A, B | NAD, MG, FUM, TTN | — |
| 7BSK | Crystal structure of human ME2 R67Q mutant | x-ray diffraction | A, B | NAD | 17 (best 0.90) |
| 7BSK | Crystal structure of human ME2 R67Q mutant | x-ray diffraction | A, B | NAD | — |
| 7BSL | Crystal Structure of human ME2 R67A mutant | x-ray diffraction | A, B | NAD | 17 (best 0.87) |
| 7BSL | Crystal structure of human ME2 R67A mutant | x-ray diffraction | A, B | NAD | — |
| 7XDE | Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in apo form | electron microscopy | A, B, C, D | NAD | 20 (best 0.85) |
| P23368 | AlphaFold monomer V2.0 prediction for NAD-dependent malic enzyme, mitochondrial (P23368) | — | — | — |
Ligands
Elsewhere
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