UniProt P23070
Retron Ec86 reverse transcriptase (P23070)
Retron Ec86 reverse transcriptase (UniProt P23070), EC 2.7.7.49: 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 68 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P23070
- Protein
- Retron Ec86 reverse transcriptase
- EC
- 2.7.7.49
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 68 · 4 records with a druggable one
Structures
7 records of P23070 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7V9U | Cryo-EM structure of E.COLI retron-EC86 (rt-msdna-RNA) at 3.2 ångström | electron microscopy | A, B | — | — |
| 7V9X | Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.8 angstrom | electron microscopy | A, B | — | 15 (best 0.80) |
| 7V9X | Cryo-EM structure of E.COLI retron-EC86 in complex with its effector at 2.8 ångström | electron microscopy | A, B | — | — |
| 8QBK | Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment) | electron microscopy | A, K, P, U | MG | 16 (best 0.81) |
| 8QBL | Retron-Eco1 filament with inactive effector (E106A, 2 segments) | electron microscopy | A, I, K, P, U, Z | MG | 18 (best 0.86) |
| 9JM0 | retron Ec86-effector fiber | electron microscopy | A, B, K, P | — | 16 (best 0.81) |
| P23070 | AlphaFold monomer V2.0 prediction for RNA-directed DNA polymerase from retron EC86 (P23070) | predicted | A | — | 3 (best 0.46) |
Ligands
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 8QBL chain I against the predicted model P23070: TM-score 0.95, RMSD 1.53 Å
- 8QBK chain K against the predicted model P23070: TM-score 0.95, RMSD 1.68 Å
- 8QBK chain A against the predicted model P23070: TM-score 0.95, RMSD 1.70 Å
- 8QBK chain U against the predicted model P23070: TM-score 0.95, RMSD 1.72 Å
- 8QBK chain P against the predicted model P23070: TM-score 0.94, RMSD 1.74 Å
- 8QBL chain A against the predicted model P23070: TM-score 0.94, RMSD 1.77 Å
- 8QBL chain K against the predicted model P23070: TM-score 0.94, RMSD 1.77 Å
- 8QBL chain U against the predicted model P23070: TM-score 0.94, RMSD 1.77 Å
- 8QBL chain P against the predicted model P23070: TM-score 0.94, RMSD 1.77 Å
- 9JM0 chain B against the predicted model P23070: TM-score 0.94, RMSD 1.77 Å
Elsewhere
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