UniProt P21888
Cysteinyl-tRNA synthetase (P21888)
Cysteinyl-tRNA synthetase (UniProt P21888), EC 6.1.1.16: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21888
- Protein
- Cysteinyl-tRNA synthetase
- EC
- 6.1.1.16
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 24 · 6 records with a druggable one
Structures
6 records of P21888 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LI5 | Crystal Structure of Cysteinyl-tRNA Synthetase | x-ray diffraction | A, B | ZN | 3 (best 0.74) |
| 1LI5 | Crystal structure of cysteinyl-tRNA synthetase | x-ray diffraction | A, B | ZN | 3 (best 0.74) |
| 1LI7 | Crystal Structure of Cysteinyl-tRNA Synthetase with Cysteine Substrate Bound | x-ray diffraction | A, B | ZN, CYS | 5 (best 0.71) |
| 1LI7 | Crystal structure of cysteinyl-tRNA synthetase with cysteine substrate bound | x-ray diffraction | A, B | ZN, CYS | 5 (best 0.71) |
| 1U0B | Crystal structure of cysteinyl-tRNA synthetase binary complex with trnacys | x-ray diffraction | B | ZN | 6 (best 0.78) |
| P21888 | AlphaFold monomer V2.0 prediction for cysteine--tRNA ligase (P21888) | predicted | A | — | 2 (best 0.62) |
Ligands
Experiment against prediction
- 1LI5 chain B against the predicted model P21888: TM-score 0.99, RMSD 0.61 Å
- 1LI5 chain B against the predicted model P21888: TM-score 0.99, RMSD 0.61 Å
- 1LI7 chain B against the predicted model P21888: TM-score 0.99, RMSD 0.65 Å
- 1LI7 chain B against the predicted model P21888: TM-score 0.99, RMSD 0.65 Å
- 1LI7 chain A against the predicted model P21888: TM-score 0.99, RMSD 0.66 Å
- 1LI7 chain A against the predicted model P21888: TM-score 0.99, RMSD 0.66 Å
- 1LI5 chain A against the predicted model P21888: TM-score 0.99, RMSD 0.66 Å
- 1LI5 chain A against the predicted model P21888: TM-score 0.99, RMSD 0.66 Å
- 1U0B chain B against the predicted model P21888: TM-score 0.97, RMSD 1.30 Å
Elsewhere
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