UniProt P21730
C5a anaphylatoxin chemotactic receptor 1 (P21730)
C5a anaphylatoxin chemotactic receptor 1 (UniProt P21730): 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P21730
- Protein
- C5a anaphylatoxin chemotactic receptor 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 38 · 7 records with a druggable one
Structures
13 records of P21730 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K3U | Structure of the tyrosine-sulfated C5a receptor N-terminus in complex with the immune evasion… | solution nmr | B | — | — |
| 5O9H | Crystal structure of thermostabilised human C5A anaphylatoxin chemotactic receptor 1 (C5AR) in… | x-ray diffraction | A, B | 9P2, OLA | — |
| 6C1Q | Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an… | x-ray diffraction | B | 9P2 | — |
| 6C1Q | Crystal structure of human C5A receptor in complex with an orthosteric antagonist PMX53 and an… | x-ray diffraction | B | ACE, 9P2 | — |
| 6C1R | Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an… | x-ray diffraction | B | EFD, NA, OLA | 3 (best 0.75) |
| 6C1R | Crystal structure of human C5A receptor in complex with an orthosteric antagonist PMX53 and an… | x-ray diffraction | B | ACE, EFD, NA, OLA | — |
| 7Y64 | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | electron microscopy | D | — | 6 (best 0.79) |
| 7Y65 | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | electron microscopy | D | — | 7 (best 0.76) |
| 7Y66 | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | electron microscopy | D | — | 5 (best 0.79) |
| 7Y67 | Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | electron microscopy | D | — | 7 (best 0.78) |
| 8GO8 | Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a… | electron microscopy | V, U | — | 4 (best 0.69) |
| 8JZZ | Structure of human C5a-desArg bound human C5aR1 in complex with Go | electron microscopy | A | — | 6 (best 0.78) |
| P21730 | AlphaFold monomer V2.0 prediction for C5A anaphylatoxin chemotactic receptor 1 (P21730) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5O9H chain B against the predicted model P21730: TM-score 0.97, RMSD 1.20 Å
- 5O9H chain A against the predicted model P21730: TM-score 0.97, RMSD 1.22 Å
- 7Y67 chain D against the predicted model P21730: TM-score 0.90, RMSD 2.48 Å
- 8JZZ chain A against the predicted model P21730: TM-score 0.90, RMSD 2.52 Å
- 7Y66 chain D against the predicted model P21730: TM-score 0.90, RMSD 2.59 Å
- 7Y65 chain D against the predicted model P21730: TM-score 0.89, RMSD 2.58 Å
- 7Y64 chain D against the predicted model P21730: TM-score 0.89, RMSD 2.65 Å
- 6C1R chain B against the predicted model P21730: TM-score 0.78, RMSD 2.07 Å
- 6C1R chain B against the predicted model P21730: TM-score 0.78, RMSD 2.07 Å
- 6C1Q chain B against the predicted model P21730: TM-score 0.77, RMSD 2.19 Å
Elsewhere
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