UniProt P21616
Pyrophosphate-energized vacuolar membrane proton pump (P21616)
Pyrophosphate-energized vacuolar membrane proton pump (UniProt P21616), EC 3.6.1.1: 13 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 31 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21616
- Protein
- Pyrophosphate-energized vacuolar membrane proton pump
- EC
- 3.6.1.1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 31 · 2 records with a druggable one
Structures
14 records of P21616 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPJ | Crystal structure of proton-pumping pyrophosphatase | x-ray diffraction | A, B, C, D | — | — |
| 6AFS | Proton pyrophosphatase - two phosphates-bound | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFS | Proton pyrophosphatase - two phosphates-bound | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFT | Proton pyrophosphatase - E301Q | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFU | Proton pyrophosphatase-L555M mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFV | Proton pyrophosphatase-L555K mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | 14 (best 0.79) |
| 6AFV | Proton pyrophosphatase-L555K mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFW | Proton pyrophosphatase-T228D mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFX | Proton pyrophosphatase - E225A | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFY | Proton pyrophosphatase-E225S mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | 17 (best 0.81) |
| 6AFY | Proton pyrophosphatase-E225S mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFZ | Proton pyrophosphatase-E225H mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| 6AFZ | Proton pyrophosphatase-E225H mutant | x-ray diffraction | A, B | PO4, MG, K, 1PG | — |
| P21616 | AlphaFold monomer V2.0 prediction for pyrophosphate-energized vacuolar membrane proton pump (P21616) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6AFX chain B against the predicted model P21616: TM-score 1.00, RMSD 0.18 Å
- 6AFW chain B against the predicted model P21616: TM-score 1.00, RMSD 0.19 Å
- 6AFT chain B against the predicted model P21616: TM-score 1.00, RMSD 0.19 Å
- 6AFY chain B against the predicted model P21616: TM-score 1.00, RMSD 0.20 Å
- 6AFY chain B against the predicted model P21616: TM-score 1.00, RMSD 0.20 Å
- 6AFS chain B against the predicted model P21616: TM-score 1.00, RMSD 0.21 Å
- 6AFS chain B against the predicted model P21616: TM-score 1.00, RMSD 0.21 Å
- 6AFU chain B against the predicted model P21616: TM-score 1.00, RMSD 0.22 Å
- 6AFY chain A against the predicted model P21616: TM-score 1.00, RMSD 0.25 Å
- 6AFY chain A against the predicted model P21616: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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