UniProt P21580
Tumor necrosis factor alpha-induced protein 3 (P21580)
Tumor necrosis factor alpha-induced protein 3 (UniProt P21580), EC 3.4.19.12, 6.3.2.-: 33 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 25 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21580
- Protein
- Tumor necrosis factor alpha-induced protein 3
- EC
- 3.4.19.12, 6.3.2.-
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 25 · 2 records with a druggable one
Structures
34 records of P21580 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EQE | Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2EQE | Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2EQF | Solution structure of the 7th A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2EQF | Solution structure of the 7TH A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2EQG | Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2EQG | Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor… | solution nmr | A | — | — |
| 2VFJ | Structure of the A20 Ovarian Tumour (OTU) domain | x-ray diffraction | A, B, C, D | — | — |
| 2VFJ | Structure of the A20 ovarian tumour (otu) domain | x-ray diffraction | A, B, C, D | — | — |
| 3DKB | Crystal Structure of A20, 2.5 angstrom | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3DKB | Crystal structure of A20, 2.5 ångström | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3OJ3 | Crystal structure of the A20 ZnF4 and ubiquitin complex | x-ray diffraction | I, J, K, L, M, N, O, P | — | — |
| 3OJ3 | Crystal structure of the A20 ZNF4 and ubiquitin complex | x-ray diffraction | I, J, K, L, M, N, O, P | — | — |
| 3OJ4 | Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex | x-ray diffraction | C, F | — | — |
| 3OJ4 | Crystal structure of the A20 ZNF4, ubiquitin and UBCH5A complex | x-ray diffraction | C, F | — | — |
| 3VUW | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I | x-ray diffraction | E, F, G | — | — |
| 3VUW | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I | x-ray diffraction | E, F, G | — | — |
| 3VUX | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II | x-ray diffraction | E, F, G | — | — |
| 3VUX | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II | x-ray diffraction | E, F, G | — | — |
| 3VUY | Crystal structure of A20 ZF7 in complex with linear tetraubiquitin | x-ray diffraction | D, F, E | — | — |
| 3VUY | Crystal structure of A20 ZF7 in complex with linear tetraubiquitin | x-ray diffraction | D, F, E | — | — |
| 3ZJD | A20 OTU domain in reduced, active state at 1.87 A resolution | x-ray diffraction | A, B | — | — |
| 3ZJD | A20 otu domain in reduced, active state at 1.87 a resolution | x-ray diffraction | A, B | — | — |
| 3ZJE | A20 OTU domain in reversibly oxidised (SOH) state | x-ray diffraction | A, B | — | — |
| 3ZJE | A20 otu domain in reversibly oxidised (soh) state | x-ray diffraction | A, B | — | — |
| 3ZJF | A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak. | x-ray diffraction | A, B | — | — |
| 3ZJF | A20 otu domain with irreversibly oxidised CYS103 from 270 min H2O2 soak. | x-ray diffraction | A, B | — | — |
| 3ZJG | A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak. | x-ray diffraction | A, B | — | — |
| 3ZJG | A20 otu domain with irreversibly oxidised CYS103 from 60 min H2O2 soak. | x-ray diffraction | A, B | — | — |
| 5LRX | Structure of A20 OTU domain bound to ubiquitin | x-ray diffraction | A, C, E, F | — | — |
| 5LRX | Structure of A20 otu domain bound to ubiquitin | x-ray diffraction | A, C, E, F | AYE | — |
| 5V3B | Human A20 otu domain (wt) with acetamidylated C103 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5V3P | Human A20 OTU domain (I325N) with acetamidylated C103 | x-ray diffraction | A, B, C, D, E, F | — | 20 (best 0.54) |
| 5V3P | Human A20 otu domain (I325N) with acetamidylated C103 | x-ray diffraction | A, B, C, D, E, F | — | — |
| P21580 | AlphaFold monomer V2.0 prediction for tumor necrosis factor alpha- induced protein 3 (P21580) | predicted | A | — | 5 (best 0.64) |
Ligands
- AYE · prop-2-en-1-amine · in 1 record
Experiment against prediction
- 5V3P chain B against the predicted model P21580: TM-score 1.00, RMSD 0.36 Å
- 5V3P chain B against the predicted model P21580: TM-score 1.00, RMSD 0.36 Å
- 5V3P chain C against the predicted model P21580: TM-score 1.00, RMSD 0.42 Å
- 5V3P chain C against the predicted model P21580: TM-score 1.00, RMSD 0.42 Å
- 5V3P chain F against the predicted model P21580: TM-score 1.00, RMSD 0.40 Å
- 5V3P chain F against the predicted model P21580: TM-score 1.00, RMSD 0.40 Å
- 5V3P chain E against the predicted model P21580: TM-score 0.99, RMSD 0.52 Å
- 5V3P chain E against the predicted model P21580: TM-score 0.99, RMSD 0.52 Å
- 5V3P chain D against the predicted model P21580: TM-score 0.99, RMSD 0.50 Å
- 5V3P chain D against the predicted model P21580: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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