UniProt P20457
DNA primase large subunit (P20457)
DNA primase large subunit (UniProt P20457), EC 2.7.7.-: 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20457
- Protein
- DNA primase large subunit
- EC
- 2.7.7.-
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 19 · 7 records with a druggable one
Structures
12 records of P20457 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LGB | Crystal Structure of the Fe-S Domain of the yeast DNA primase | x-ray diffraction | A, B | — | — |
| 3LGB | Crystal structure of the fe-S domain of the yeast DNA primase | x-ray diffraction | A, B | — | — |
| 6DTV | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain Y395F mutant | x-ray diffraction | A | SF4 | 2 (best 0.59) |
| 6DTV | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain Y395F mutant | x-ray diffraction | A | SF4 | — |
| 6DTZ | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain, Y397F mutant | x-ray diffraction | A | SF4 | 2 (best 0.60) |
| 6DTZ | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain, Y397F mutant | x-ray diffraction | A | SF4 | 2 (best 0.60) |
| 6DU0 | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain Y395L mutant | x-ray diffraction | A | SF4 | 2 (best 0.64) |
| 6DU0 | Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain Y395L mutant | x-ray diffraction | A | SF4 | — |
| 8B9A | S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA… | electron microscopy | A | — | 1 (best 0.79) |
| 8B9B | S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate… | electron microscopy | A | — | — |
| 8B9C | S. cerevisiae pol alpha - replisome complex | electron microscopy | A | — | 1 (best 0.78) |
| P20457 | AlphaFold monomer V2.0 prediction for DNA primase large subunit (P20457) | predicted | A | — | 9 (best 0.66) |
Ligands
- SF4 · Iron/sulfur cluster · in 6 records
Experiment against prediction
- 3LGB chain A against the predicted model P20457: TM-score 0.99, RMSD 0.49 Å
- 3LGB chain A against the predicted model P20457: TM-score 0.99, RMSD 0.49 Å
- 3LGB chain B against the predicted model P20457: TM-score 0.99, RMSD 0.56 Å
- 3LGB chain B against the predicted model P20457: TM-score 0.99, RMSD 0.56 Å
- 6DU0 chain A against the predicted model P20457: TM-score 0.98, RMSD 0.87 Å
- 6DU0 chain A against the predicted model P20457: TM-score 0.98, RMSD 0.87 Å
- 6DTZ chain A against the predicted model P20457: TM-score 0.97, RMSD 1.09 Å
- 6DTZ chain A against the predicted model P20457: TM-score 0.97, RMSD 1.09 Å
- 6DTV chain A against the predicted model P20457: TM-score 0.97, RMSD 1.10 Å
- 6DTV chain A against the predicted model P20457: TM-score 0.97, RMSD 1.10 Å
Elsewhere
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