UniProt P19474
E3 ubiquitin-protein ligase TRIM21 (P19474)
E3 ubiquitin-protein ligase TRIM21 (UniProt P19474), EC 2.3.2.27: 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P19474
- Protein
- E3 ubiquitin-protein ligase TRIM21
- EC
- 2.3.2.27
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 42 · 5 records with a druggable one
Structures
14 records of P19474 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IWG | Complex between the pryspry domain of TRIM21 and IgG Fc | x-ray diffraction | B, E | — | — |
| 2IWG | Complex between the pryspry domain of TRIM21 and IgG Fc | x-ray diffraction | B, E | — | — |
| 5JPX | Solution structure of the TRIM21 B-box2 (B2) | solution nmr | A | ZN | — |
| 5JPX | Solution structure of the TRIM21 B-BOX2 (B2) | solution nmr | A | — | — |
| 5OLM | TRIM21 | x-ray diffraction | A, B | ZN | 1 (best 0.51) |
| 5OLM | TRIM21 | x-ray diffraction | A, B | ZN | — |
| 6FGA | Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating… | x-ray diffraction | A, B, C, D, E, F, G, H | ZN | 20 (best 0.67) |
| 6FGA | Crystal structure of TRIM21 E3 ligase, ring domain in complex with its cognate E2 conjugating… | x-ray diffraction | A, B, C, D, E, F, G, H | ZN | — |
| 6S53 | Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin… | x-ray diffraction | B, A, H, G | ZN | 15 (best 0.76) |
| 6S53 | Crystal structure of TRIM21 ring domain in complex with an isopeptide- linked UBE2N~UBIQUITIN… | x-ray diffraction | B, A, H, G | ZN | — |
| 7BBD | Crystal structure of monoubiquitinated TRIM21 ring (ub-ring) in complex with ubiquitin charged… | x-ray diffraction | B | ZN | — |
| 8Y58 | Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine. | x-ray diffraction | A | PMZ | 1 (best 0.51) |
| 8Y5B | Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (R)-hydroxyl-acepromazine. | x-ray diffraction | A | A1D5Z | 1 (best 0.52) |
| P19474 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM21 (P19474) | predicted | A | — | 4 (best 0.48) |
Ligands
Experiment against prediction
- 2IWG chain B against the predicted model P19474: TM-score 0.99, RMSD 0.63 Å
- 2IWG chain B against the predicted model P19474: TM-score 0.99, RMSD 0.63 Å
- 8Y5B chain A against the predicted model P19474: TM-score 0.98, RMSD 0.88 Å
- 8Y58 chain A against the predicted model P19474: TM-score 0.98, RMSD 0.92 Å
- 6S53 chain A against the predicted model P19474: TM-score 0.97, RMSD 0.58 Å
- 6S53 chain G against the predicted model P19474: TM-score 0.96, RMSD 0.66 Å
- 6S53 chain G against the predicted model P19474: TM-score 0.96, RMSD 0.66 Å
- 6S53 chain B against the predicted model P19474: TM-score 0.96, RMSD 0.75 Å
- 6S53 chain B against the predicted model P19474: TM-score 0.96, RMSD 0.75 Å
- 6S53 chain H against the predicted model P19474: TM-score 0.96, RMSD 0.69 Å
Elsewhere
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