UniProt P19387
DNA-directed RNA polymerase II subunit RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (UniProt P19387): 18 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P19387
- Protein
- DNA-directed RNA polymerase II subunit RPB3
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 22 · 4 records with a druggable one
Structures
19 records of P19387 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | C | ZN | 4 (best 0.87) |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | C | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | C | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | C | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | C | ZN | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | C | — | — |
| 5IYA | Human core-PIC in the closed state | electron microscopy | C | ZN | — |
| 5IYA | Human core-pic in the closed state | electron microscopy | C | — | — |
| 5IYB | Human core-PIC in the open state | electron microscopy | C | ZN | 4 (best 0.86) |
| 5IYB | Human core-pic in the open state | electron microscopy | C | — | — |
| 5IYC | Human core-PIC in the initial transcribing state | electron microscopy | C | ZN | 3 (best 0.89) |
| 5IYC | Human core-pic in the initial transcribing state | electron microscopy | C | — | — |
| 5IYD | Human core-PIC in the initial transcribing state (no IIS) | electron microscopy | C | — | — |
| 5IYD | Human core-pic in the initial transcribing state (no iis) | electron microscopy | C | — | — |
| 6DRD | RNA Pol II(G) | electron microscopy | C | ZN | 6 (best 0.87) |
| 6DRD | RNA pol II(G) | electron microscopy | C | ZN | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | C | ZN | — |
| 6XRE | Structure of the P53/RNA polymerase II assembly | electron microscopy | C | ZN | — |
| P19387 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB3 (P19387) | predicted | A | — | 5 (best 0.40) |
Ligands
- ZN · Zinc ion · in 9 records
Experiment against prediction
- 6DRD chain C against the predicted model P19387: TM-score 0.98, RMSD 0.78 Å
- 6DRD chain C against the predicted model P19387: TM-score 0.98, RMSD 0.78 Å
- 5IYD chain C against the predicted model P19387: TM-score 0.95, RMSD 1.64 Å
- 5IYD chain C against the predicted model P19387: TM-score 0.95, RMSD 1.64 Å
- 5IY9 chain C against the predicted model P19387: TM-score 0.95, RMSD 1.65 Å
- 5IY9 chain C against the predicted model P19387: TM-score 0.95, RMSD 1.65 Å
- 5IYB chain C against the predicted model P19387: TM-score 0.94, RMSD 1.64 Å
- 5IYB chain C against the predicted model P19387: TM-score 0.94, RMSD 1.64 Å
- 5IYC chain C against the predicted model P19387: TM-score 0.94, RMSD 1.61 Å
- 5IYC chain C against the predicted model P19387: TM-score 0.94, RMSD 1.61 Å
Elsewhere
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