UniProt P19263
Mediator of RNA polymerase II transcription subunit 14 (P19263)
Mediator of RNA polymerase II transcription subunit 14 (UniProt P19263): 9 experimental structures and 1 predicted model on GenesisL1, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19263
- Protein
- Mediator of RNA polymerase II transcription subunit 14
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 21 · 8 records with a druggable one
Structures
10 records of P19263 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | l | — | 1 (best 0.79) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | l | — | — |
| 7UI9 | Core Mediator-PICearly (Copy A) | electron microscopy | n | — | 3 (best 0.84) |
| 7UIC | Mediator-PIC Early (Tail A) | electron microscopy | n | — | 3 (best 0.76) |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | n | — | 2 (best 0.85) |
| 7UIG | Mediator-PIC Early (Mediator A) | electron microscopy | n | — | 4 (best 0.84) |
| 7UIK | Mediator-PIC Early (Tail A + Upstream DNA & Activator) | electron microscopy | n | — | 4 (best 0.80) |
| 7UIL | Mediator-PIC Early (Tail A/B Dimer) | electron microscopy | n, 4 | — | 3 (best 0.80) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | An, Bn | — | 1 (best 0.81) |
| P19263 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 14… | predicted | A | — | — |
Experiment against prediction
- 7UIL chain n against the predicted model P19263: TM-score 0.93, RMSD 1.61 Å
- 7UIC chain n against the predicted model P19263: TM-score 0.93, RMSD 1.61 Å
- 7UIL chain 4 against the predicted model P19263: TM-score 0.93, RMSD 1.61 Å
- 7UIK chain n against the predicted model P19263: TM-score 0.93, RMSD 1.61 Å
- 7UIO chain Bn against the predicted model P19263: TM-score 0.79, RMSD 3.65 Å
- 7UIO chain An against the predicted model P19263: TM-score 0.79, RMSD 3.65 Å
- 7UIG chain n against the predicted model P19263: TM-score 0.74, RMSD 3.19 Å
- 7UI9 chain n against the predicted model P19263: TM-score 0.74, RMSD 3.19 Å
- 7UIF chain n against the predicted model P19263: TM-score 0.74, RMSD 3.19 Å
- 5OQM chain l against the predicted model P19263: TM-score 0.57, RMSD 4.00 Å
Elsewhere
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