UniProt P18858
DNA ligase 1 (P18858)
DNA ligase 1 (UniProt P18858), EC 6.5.1.1: 34 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 142 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18858
- Protein
- DNA ligase 1
- EC
- 6.5.1.1
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 142 · 17 records with a druggable one
Structures
35 records of P18858 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X9N | Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA | x-ray diffraction | A | — | — |
| 1X9N | Crystal structure of human DNA ligase I bound to 5'-adenylated, nicked DNA | x-ray diffraction | A | — | — |
| 6P09 | Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | x-ray diffraction | A | MG, AMP | 8 (best 0.84) |
| 6P09 | Human DNA ligase 1 bound to an adenylated, dideoxy terminated DNA nick with 200 mm MG2+ | x-ray diffraction | A | MG | — |
| 6P0A | Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 2 mM Mg2+ | x-ray diffraction | A | MG, AMP | 8 (best 0.83) |
| 6P0A | Human DNA ligase 1 bound to an adenylated, dideoxy terminated DNA nick with 2 mm MG2+ | x-ray diffraction | A | MG | — |
| 6P0B | Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM… | x-ray diffraction | A | MG, AMP | 7 (best 0.84) |
| 6P0B | Human DNA ligase 1 (E346A/E592A) bound to an adenylated, dideoxy terminated DNA nick with 200 mm… | x-ray diffraction | A | MG | — |
| 6P0C | Human DNA Ligase 1 Bound to an Adenylated, hydroxyl terminated DNA nick in EDTA | x-ray diffraction | A | AMP | 6 (best 0.84) |
| 6P0C | Human DNA ligase 1 bound to an adenylated, hydroxyl terminated DNA nick in edta | x-ray diffraction | A | — | — |
| 6P0D | Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick | x-ray diffraction | A | — | — |
| 6P0D | Human DNA ligase 1 (E346A/E592A) bound to an adenylated, hydroxyl terminated DNA nick | x-ray diffraction | A | — | — |
| 6P0E | Human DNA ligase 1 (E346A,E592A) bound to adenylated DNA containing an 8-oxo GUANINE:ADENINE… | x-ray diffraction | A | — | — |
| 6Q1V | Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick | x-ray diffraction | A | AMP | 8 (best 0.84) |
| 6Q1V | Human DNA ligase 1 (E592R) bound to an adenylated, hydroxyl terminated DNA nick | x-ray diffraction | A | — | — |
| 7KR3 | Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate | x-ray diffraction | A | AMP | 7 (best 0.84) |
| 7KR3 | Human DNA ligase 1(E346A/E592A) bound to a bulged DNA substrate | x-ray diffraction | A | — | — |
| 7KR4 | Human DNA ligase 1(E346A/E592A) bound to a nicked DNA substrate control duplex | x-ray diffraction | A | — | — |
| 7L34 | Human DNA ligase 1 - R641L nicked DNA complex | x-ray diffraction | A | — | — |
| 7L35 | Human DNA Ligase 1 - R771W nicked DNA complex | x-ray diffraction | A | AMP | 6 (best 0.84) |
| 7L35 | Human DNA ligase 1 - R771W nicked DNA complex | x-ray diffraction | A | — | — |
| 7QO1 | complex of DNA ligase I and FEN1 on PCNA and DNA | electron microscopy | A | AMP | 13 (best 0.84) |
| 7SUM | Crystal structure of human ligase I with nick duplexes containing cognate A:T | x-ray diffraction | A | AMP | — |
| 7SX5 | Crystal structure of ligase I with nick duplexes containing mismatch A:C | x-ray diffraction | A | AMP | 9 (best 0.84) |
| 7SX5 | Crystal structure of ligase I with nick duplexes containing mismatch A:C | x-ray diffraction | A | AMP | — |
| 7SXE | Crystal structure of ligase I with nick duplexes containing cognate G:T | x-ray diffraction | A | AMP | 7 (best 0.84) |
| 7SXE | Crystal structure of ligase I with nick duplexes containing cognate G:T | x-ray diffraction | A | AMP | — |
| 8B8T | Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP | electron microscopy | A | — | 7 (best 0.77) |
| 8VDN | DNA Ligase 1 with nick dG:C | x-ray diffraction | A | AMP | 6 (best 0.84) |
| 8VDS | DNA Ligase 1 with nick DNA 3'rG:C | x-ray diffraction | A | — | 7 (best 0.80) |
| 8VDT | DNA Ligase 1 with nick DNA 3'rA:T | x-ray diffraction | A | PO4 | 14 (best 0.74) |
| 8VZL | DNA Ligase 1 captured with pre-step 3 ligation at the rG:C nicksite | x-ray diffraction | A | AMP | 8 (best 0.80) |
| 8VZM | DNA Ligase 1 captured with pre-step 3 ligation at the rA:T nicksite | x-ray diffraction | A | AMP | 8 (best 0.84) |
| 9BS4 | DNA Ligase 1 E346A/E592A double mutant with 5'-rG:C | x-ray diffraction | A, E | AMP | 13 (best 0.87) |
| P18858 | AlphaFold monomer V2.0 prediction for DNA ligase 1 (P18858) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6P0D chain A against the predicted model P18858: TM-score 1.00, RMSD 0.35 Å
- 6P0D chain A against the predicted model P18858: TM-score 1.00, RMSD 0.35 Å
- 6P0E chain A against the predicted model P18858: TM-score 1.00, RMSD 0.40 Å
- 6P0C chain A against the predicted model P18858: TM-score 1.00, RMSD 0.39 Å
- 6P0C chain A against the predicted model P18858: TM-score 1.00, RMSD 0.39 Å
- 6Q1V chain A against the predicted model P18858: TM-score 1.00, RMSD 0.42 Å
- 6Q1V chain A against the predicted model P18858: TM-score 1.00, RMSD 0.42 Å
- 6P09 chain A against the predicted model P18858: TM-score 1.00, RMSD 0.44 Å
- 6P09 chain A against the predicted model P18858: TM-score 1.00, RMSD 0.44 Å
- 6P0B chain A against the predicted model P18858: TM-score 1.00, RMSD 0.47 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.