UniProt P18627
Lymphocyte activation gene 3 protein (P18627)
Lymphocyte activation gene 3 protein (UniProt P18627): 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18627
- Protein
- Lymphocyte activation gene 3 protein
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 55 · 7 records with a druggable one
Structures
9 records of P18627 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7TZG | Structure of human LAG3 in complex with antibody single-chain variable fragment | x-ray diffraction | C, D | NAG | 10 (best 0.71) |
| 7TZG | Structure of human LAG3 in complex with antibody single-chain variable fragment | x-ray diffraction | C, D | NAG | 10 (best 0.71) |
| 7TZH | Structure of human LAG3 domains 3-4 in complex with antibody single chain-variable fragment | x-ray diffraction | D, B | NAG | 5 (best 0.70) |
| 7TZH | Structure of human LAG3 domains 3-4 in complex with antibody single chain-variable fragment | x-ray diffraction | D, B | NAG | 5 (best 0.70) |
| 7UM3 | Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion | x-ray diffraction | B, A | — | — |
| 8SO3 | CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 | electron microscopy | D, X | NAG | 10 (best 0.71) |
| 8SR0 | CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined | electron microscopy | X, D | NAG | 10 (best 0.70) |
| 9BF9 | Human LAG-3-HLA-DR1 complex | x-ray diffraction | D | NAG, SO4 | 4 (best 0.80) |
| P18627 | AlphaFold monomer V2.0 prediction for lymphocyte activation gene 3 protein (P18627) | predicted | A | — | 1 (best 0.30) |
Ligands
Experiment against prediction
- 9BF9 chain D against the predicted model P18627: TM-score 0.92, RMSD 1.92 Å
- 7TZH chain D against the predicted model P18627: TM-score 0.91, RMSD 1.99 Å
- 7TZH chain D against the predicted model P18627: TM-score 0.91, RMSD 1.99 Å
- 7TZH chain B against the predicted model P18627: TM-score 0.89, RMSD 2.19 Å
- 7TZH chain B against the predicted model P18627: TM-score 0.89, RMSD 2.19 Å
- 8SR0 chain X against the predicted model P18627: TM-score 0.87, RMSD 2.22 Å
- 8SR0 chain D against the predicted model P18627: TM-score 0.86, RMSD 2.38 Å
- 8SO3 chain D against the predicted model P18627: TM-score 0.86, RMSD 2.28 Å
- 8SO3 chain X against the predicted model P18627: TM-score 0.86, RMSD 2.33 Å
- 7TZG chain C against the predicted model P18627: TM-score 0.82, RMSD 3.46 Å
Elsewhere
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