UniProt P18484
AP-2 complex subunit alpha-2 (P18484)
AP-2 complex subunit alpha-2 (UniProt P18484): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18484
- Protein
- AP-2 complex subunit alpha-2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 36 · 3 records with a druggable one
Structures
11 records of P18484 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | A | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | A | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | A | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | A | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | A | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | A | — | — |
| 7OG1 | AP2 clathrin adaptor core in complex with cargo peptide and FCHO2 | x-ray diffraction | AAA | — | 12 (best 0.82) |
| 7OHO | Crystal structure of AP2 FCHO2 chimera | x-ray diffraction | AAA | IHP | 12 (best 0.85) |
| 7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on Cmu2 subunit | electron microscopy | A | — | 12 (best 0.82) |
| 7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on CMU2 subunit | electron microscopy | A | — | — |
| P18484 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit alpha-2 (P18484) | predicted | A | — | — |
Ligands
- IHP · Inositol hexakisphosphate · in 1 record
Experiment against prediction
- 7Z5C chain A against the predicted model P18484: TM-score 0.88, RMSD 3.25 Å
- 7Z5C chain A against the predicted model P18484: TM-score 0.88, RMSD 3.25 Å
- 6YAF chain A against the predicted model P18484: TM-score 0.88, RMSD 3.29 Å
- 6YAF chain A against the predicted model P18484: TM-score 0.88, RMSD 3.29 Å
- 6YAH chain A against the predicted model P18484: TM-score 0.88, RMSD 3.29 Å
- 6YAH chain A against the predicted model P18484: TM-score 0.88, RMSD 3.29 Å
- 7OHO chain AAA against the predicted model P18484: TM-score 0.85, RMSD 3.84 Å
- 4UQI chain A against the predicted model P18484: TM-score 0.85, RMSD 3.84 Å
- 4UQI chain A against the predicted model P18484: TM-score 0.85, RMSD 3.84 Å
- 7OG1 chain AAA against the predicted model P18484: TM-score 0.79, RMSD 4.30 Å
Elsewhere
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