UniProt P18420
Proteasome subunit alpha type-1 (P18420)
Proteasome subunit alpha type-1 (UniProt P18420), EC 3.4.25.1: 8 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18420
- Protein
- Proteasome subunit alpha type-1
- EC
- 3.4.25.1
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 10 · 3 records with a druggable one
Structures
9 records of P18420 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EPC | Ground state 26S proteasome (GS2) | electron microscopy | F | — | 3 (best 0.84) |
| 6EPC | Ground state 26S proteasome (GS2) | electron microscopy | F | — | — |
| 6EPD | Substrate processing state 26S proteasome (SPS1) | electron microscopy | F | — | 3 (best 0.81) |
| 6EPD | Substrate processing state 26S proteasome (SPS1) | electron microscopy | F | — | — |
| 6EPE | Substrate processing state 26S proteasome (SPS2) | electron microscopy | F | — | 3 (best 0.86) |
| 6EPE | Substrate processing state 26S proteasome (SPS2) | electron microscopy | F | — | — |
| 6EPF | Ground state 26S proteasome (GS1) | electron microscopy | F | — | — |
| 6TU3 | Rat 20S proteasome | electron microscopy | F, T | — | — |
| P18420 | AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-1 (P18420) | predicted | A | — | 1 (best 0.32) |
Experiment against prediction
- 6TU3 chain F against the predicted model P18420: TM-score 0.98, RMSD 0.78 Å
- 6EPE chain F against the predicted model P18420: TM-score 0.96, RMSD 1.34 Å
- 6EPE chain F against the predicted model P18420: TM-score 0.96, RMSD 1.34 Å
- 6EPC chain F against the predicted model P18420: TM-score 0.95, RMSD 1.45 Å
- 6EPC chain F against the predicted model P18420: TM-score 0.95, RMSD 1.45 Å
- 6EPF chain F against the predicted model P18420: TM-score 0.95, RMSD 1.52 Å
- 6EPD chain F against the predicted model P18420: TM-score 0.93, RMSD 1.80 Å
- 6EPD chain F against the predicted model P18420: TM-score 0.93, RMSD 1.80 Å
Elsewhere
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