UniProt P18014
Probable E3 ubiquitin-protein ligase ipaH7.8 (P18014)
Probable E3 ubiquitin-protein ligase ipaH7.8 (UniProt P18014), EC 2.3.2.27: 4 experimental structures and 1 predicted model on GenesisL1, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P18014
- Protein
- Probable E3 ubiquitin-protein ligase ipaH7.8
- EC
- 2.3.2.27
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 22 · 4 records with a druggable one
Structures
5 records of P18014 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WJQ | Crystal structure of GSDMB in complex with Ipah7.8 | x-ray diffraction | A | — | 4 (best 0.69) |
| 8EFP | CryoEM structure of GSDMB in complex with shigella IpaH7.8 | electron microscopy | B | — | 4 (best 0.59) |
| 8GTJ | Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex | x-ray diffraction | B, D | — | 11 (best 0.82) |
| 8GTK | Crystal structure of IpaH7.8-LRR and GSDMB isoform-1 complex | x-ray diffraction | B | — | 3 (best 0.50) |
| P18014 | AlphaFold monomer V2.0 prediction for probable E3 ubiquitin-protein ligase IPAH7.8 (P18014) | predicted | A | — | — |
Experiment against prediction
- 8GTK chain B against the predicted model P18014: TM-score 0.98, RMSD 0.89 Å
- 7WJQ chain A against the predicted model P18014: TM-score 0.97, RMSD 1.13 Å
- 8GTJ chain B against the predicted model P18014: TM-score 0.97, RMSD 1.11 Å
- 8GTJ chain D against the predicted model P18014: TM-score 0.96, RMSD 1.25 Å
- 8EFP chain B against the predicted model P18014: TM-score 0.92, RMSD 1.86 Å
Elsewhere
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