UniProt P17405
Sphingomyelin phosphodiesterase (P17405)
Sphingomyelin phosphodiesterase (UniProt P17405), EC 3.1.4.12: 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P17405
- Protein
- Sphingomyelin phosphodiesterase
- EC
- 3.1.4.12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 5 · 2 records with a druggable one
Structures
9 records of P17405 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5I81 | aSMase with zinc | x-ray diffraction | A | NAG, BMA, ZN, SO4 | 3 (best 0.59) |
| 5I81 | Asmase with zinc | x-ray diffraction | A | — | — |
| 5I85 | aSMase with zinc and phosphocholine | x-ray diffraction | A | NAG, MAN, ZN, SO4, PC | 2 (best 0.61) |
| 5I85 | Asmase with zinc and phosphocholine | x-ray diffraction | A | — | — |
| 5I8R | aSMase with zinc | x-ray diffraction | A, B, C | NAG, ZN | — |
| 5I8R | Asmase with zinc | x-ray diffraction | A, B, C | — | — |
| 5JG8 | Crystal structure of human acid sphingomyelinase | x-ray diffraction | A, B | NAG, ZN | — |
| 5JG8 | Crystal structure of human acid sphingomyelinase | x-ray diffraction | A, B | — | — |
| P17405 | AlphaFold monomer V2.0 prediction for sphingomyelin phosphodiesterase (P17405) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5I81 chain A against the predicted model P17405: TM-score 1.00, RMSD 0.34 Å
- 5I81 chain A against the predicted model P17405: TM-score 1.00, RMSD 0.34 Å
- 5I85 chain A against the predicted model P17405: TM-score 1.00, RMSD 0.35 Å
- 5I85 chain A against the predicted model P17405: TM-score 1.00, RMSD 0.35 Å
- 5I8R chain A against the predicted model P17405: TM-score 1.00, RMSD 0.36 Å
- 5I8R chain A against the predicted model P17405: TM-score 1.00, RMSD 0.36 Å
- 5I8R chain C against the predicted model P17405: TM-score 1.00, RMSD 0.38 Å
- 5I8R chain C against the predicted model P17405: TM-score 1.00, RMSD 0.38 Å
- 5I8R chain B against the predicted model P17405: TM-score 1.00, RMSD 0.49 Å
- 5I8R chain B against the predicted model P17405: TM-score 1.00, RMSD 0.49 Å
Elsewhere
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