UniProt P16333
Cytoplasmic protein NCK1 (P16333)
Cytoplasmic protein NCK1 (UniProt P16333): 24 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P16333
- Protein
- Cytoplasmic protein NCK1
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 2 · 0 records with a druggable one
Structures
25 records of P16333 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CI8 | sh2 domain of human nck1 adaptor protein - uncomplexed | x-ray diffraction | A | — | — |
| 2CI8 | SH2 domain of human NCK1 adaptor protein - uncomplexed | x-ray diffraction | A | — | — |
| 2CI9 | Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir | x-ray diffraction | A, B | — | — |
| 2CI9 | NCK1 SH2-domain in complex with a dodecaphosphopeptide from epec protein tir | x-ray diffraction | A, B | — | — |
| 2CUB | Solution structure of the SH3 domain of the human cytoplasmic protein Nck1 | solution nmr | A | — | — |
| 2CUB | Solution structure of the SH3 domain of the human cytoplasmic protein NCK1 | solution nmr | A | — | — |
| 2JS0 | Solution structure of second SH3 domain of adaptor Nck | solution nmr | A | — | — |
| 2JS0 | Solution structure of second SH3 domain of adaptor nck | solution nmr | A | — | — |
| 2JS2 | Solution structure of first SH3 domain of adaptor Nck | solution nmr | A | — | — |
| 2JS2 | Solution structure of first SH3 domain of adaptor nck | solution nmr | A | — | — |
| 2JW4 | NMR solution structure of the N-terminal SH3 domain of human Nckalpha | solution nmr | A | — | — |
| 2JW4 | NMR solution structure of the N-terminal SH3 domain of human nckalpha | solution nmr | A | — | — |
| 5QU1 | Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A | x-ray diffraction | A, B | SO4 | — |
| 5QU1 | Crystal structure of the monomeric human nck SH3.1 domain, triclinic, 1.08A | x-ray diffraction | A, B | SO4 | — |
| 5QU2 | Crystal Structure of human Nck SH3.1 in complex with peptide PPPVPNPDY | x-ray diffraction | A, B | SO4 | — |
| 5QU2 | Crystal structure of human nck SH3.1 in complex with peptide pppvpnpdy | x-ray diffraction | A, B | ACE, NH2, SO4 | — |
| 5QU3 | Crystal Structure of domain swapped human Nck SH3.1, 1.01A, monoclinic | x-ray diffraction | A, B | — | — |
| 5QU3 | Crystal structure of domain swapped human nck SH3.1, 1.01A, monoclinic | x-ray diffraction | A, B | — | — |
| 5QU4 | Crystal structure of swapped human nck SH3.1 domain, 1.05A, orthorhombic form I | x-ray diffraction | A, B, C, D | — | — |
| 5QU5 | Domain swap in the first SH3 domain of human NCK1 | x-ray diffraction | A, B | — | — |
| 5QU6 | Crystal structure of swapped human nck SH3.1 domain, 1.8A, triclinic | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 | — | — |
| 5QU7 | Crystal structure of swapped human nck SH3.1 domain, 1.3A, orthorhombic form III | x-ray diffraction | A, B | — | — |
| 5QU8 | Crystal structure of symmetric swapped human nck SH3.1 domain, 0.93A, orthorhombic form IV | x-ray diffraction | A | NA | — |
| 5QUA | Crystal structure of swapped human nck SH3.1 domain, 1.5A, C2221 | x-ray diffraction | A, B | — | — |
| P16333 | AlphaFold monomer V2.0 prediction for cytoplasmic protein NCK1 (P16333) | predicted | A | — | 2 (best 0.36) |
Ligands
Experiment against prediction
- 5QU2 chain A against the predicted model P16333: TM-score 0.98, RMSD 0.34 Å
- 5QU2 chain A against the predicted model P16333: TM-score 0.98, RMSD 0.34 Å
- 5QU2 chain B against the predicted model P16333: TM-score 0.97, RMSD 0.59 Å
- 5QU2 chain B against the predicted model P16333: TM-score 0.97, RMSD 0.59 Å
- 5QU1 chain A against the predicted model P16333: TM-score 0.97, RMSD 0.52 Å
- 5QU1 chain A against the predicted model P16333: TM-score 0.97, RMSD 0.52 Å
- 2CI9 chain B against the predicted model P16333: TM-score 0.95, RMSD 1.14 Å
- 2CI9 chain B against the predicted model P16333: TM-score 0.95, RMSD 1.14 Å
- 2CI9 chain A against the predicted model P16333: TM-score 0.93, RMSD 1.22 Å
- 2CI9 chain A against the predicted model P16333: TM-score 0.93, RMSD 1.22 Å
Elsewhere
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