UniProt P16066
Atrial natriuretic peptide receptor 1 (P16066)
Atrial natriuretic peptide receptor 1 (UniProt P16066), EC 4.6.1.2: 5 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P16066
- Protein
- Atrial natriuretic peptide receptor 1
- EC
- 4.6.1.2
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 68 · 5 records with a druggable one
Structures
6 records of P16066 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8TG9 | Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381 | electron microscopy | A, B | NAG, BMA, MAN | 15 (best 0.82) |
| 8TGA | Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound | electron microscopy | B, A | — | 12 (best 0.70) |
| 9BCN | Extracellular domain of apo GC-A, state 2 | electron microscopy | A, B | NAG, MAN, CL | 7 (best 0.66) |
| 9BCO | Intracellular domain of apo GC-A | electron microscopy | A, B | ATP | 19 (best 0.81) |
| 9BCP | Kinase homology domain of apo GC-A | electron microscopy | B, A | ATP | 15 (best 0.77) |
| P16066 | AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P16066) | predicted | A | — | — |
Ligands
Experiment against prediction
- 9BCN chain A against the predicted model P16066: TM-score 0.98, RMSD 1.11 Å
- 9BCN chain B against the predicted model P16066: TM-score 0.98, RMSD 1.11 Å
- 8TGA chain B against the predicted model P16066: TM-score 0.98, RMSD 1.20 Å
- 8TGA chain A against the predicted model P16066: TM-score 0.98, RMSD 1.21 Å
- 8TG9 chain A against the predicted model P16066: TM-score 0.98, RMSD 1.22 Å
- 8TG9 chain B against the predicted model P16066: TM-score 0.98, RMSD 1.24 Å
- 9BCP chain B against the predicted model P16066: TM-score 0.90, RMSD 2.11 Å
- 9BCP chain A against the predicted model P16066: TM-score 0.88, RMSD 2.25 Å
- 9BCO chain B against the predicted model P16066: TM-score 0.60, RMSD 5.94 Å
- 9BCO chain A against the predicted model P16066: TM-score 0.59, RMSD 6.09 Å
Elsewhere
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