UniProt P15646
rRNA 2'-O-methyltransferase fibrillarin (P15646)
rRNA 2'-O-methyltransferase fibrillarin (UniProt P15646), EC 2.1.1.-: 18 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15646
- Protein
- rRNA 2'-O-methyltransferase fibrillarin
- EC
- 2.1.1.-
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 9 · 3 records with a druggable one
Structures
19 records of P15646 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WLC | The complete structure of the small subunit processome | electron microscopy | SC, SD | — | — |
| 5WYK | Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP) | electron microscopy | 3B, 3C | — | — |
| 6LQP | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A) | electron microscopy | 3B, 3C | — | — |
| 6LQQ | Cryo-EM structure of 90S small subunit preribosomes in transition states (State B) | electron microscopy | 3B, 3C | — | — |
| 6LQR | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C) | electron microscopy | 3B, 3C | — | — |
| 6LQS | Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) | electron microscopy | 3B, 3C | — | — |
| 6LQT | Cryo-EM structure of 90S small subunit preribosomes in transition states (State E) | electron microscopy | 3B, 3C | — | — |
| 6LQU | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1) | electron microscopy | 3B, 3C | — | — |
| 6LQV | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1) | electron microscopy | 3B, 3C | — | — |
| 6ND4 | Conformational switches control early maturation of the eukaryotic small ribosomal subunit | electron microscopy | c, d | — | — |
| 6ND4 | Conformational switches control early maturation of the eukaryotic small ribosomal subunit | electron microscopy | c, d | — | — |
| 6ZDT | Crystal structure of eukaryotic Fibrillarin with Nop56 N-terminal domain | x-ray diffraction | A | — | 3 (best 0.50) |
| 6ZDT | Crystal structure of eukaryotic fibrillarin with NOP56 N-terminal domain | x-ray diffraction | A | — | — |
| 6ZQC | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1 | electron microscopy | CA, CB | — | 1 (best 0.84) |
| 6ZQE | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala) | electron microscopy | CA, CB | — | 3 (best 0.85) |
| 7AJT | Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome) | electron microscopy | CA, CB | — | — |
| 7D5T | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) | electron microscopy | 3B, 3C | — | — |
| 7SUK | Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted… | electron microscopy | SC, SD | — | 2 (best 0.85) |
| P15646 | AlphaFold monomer V2.0 prediction for rRNA 2'-O-methyltransferase fibrillarin (P15646) | predicted | A | — | — |
Experiment against prediction
- 6ZDT chain A against the predicted model P15646: TM-score 0.99, RMSD 0.60 Å
- 6ZDT chain A against the predicted model P15646: TM-score 0.99, RMSD 0.60 Å
- 6LQP chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.80 Å
- 6LQQ chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.80 Å
- 6LQR chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.80 Å
- 6LQU chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.80 Å
- 6LQV chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.80 Å
- 7D5T chain 3C against the predicted model P15646: TM-score 0.98, RMSD 0.77 Å
- 6LQS chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.84 Å
- 6LQT chain 3B against the predicted model P15646: TM-score 0.98, RMSD 0.84 Å
Elsewhere
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