UniProt P15042
DNA ligase (P15042)
DNA ligase (UniProt P15042), EC 6.5.1.2: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15042
- Protein
- DNA ligase
- EC
- 6.5.1.2
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 1 record with a druggable one
Structures
7 records of P15042 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OWO | Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate | x-ray diffraction | A | — | — |
| 2OWO | Last stop on the road to repair: structure of E.COLI DNA ligase bound to nicked DNA-adenylate | x-ray diffraction | A | — | — |
| 4GLX | DNA ligase A in complex with inhibitor | x-ray diffraction | A | — | — |
| 4GLX | DNA ligase a in complex with inhibitor | x-ray diffraction | A | — | — |
| 5TT5 | Escherichia coli LigA (K115M) in complex with NAD+ | x-ray diffraction | A | NAD, ZN, MG | 4 (best 0.84) |
| 5TT5 | Escherichia COLI liga (K115M) in complex with NAD+ | x-ray diffraction | A | NAD, ZN, MG | — |
| P15042 | AlphaFold monomer V2.0 prediction for DNA ligase (P15042) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5TT5 chain A against the predicted model P15042: TM-score 0.60, RMSD 4.66 Å
- 5TT5 chain A against the predicted model P15042: TM-score 0.60, RMSD 4.66 Å
- 4GLX chain A against the predicted model P15042: TM-score 0.48, RMSD 3.44 Å
- 4GLX chain A against the predicted model P15042: TM-score 0.48, RMSD 3.44 Å
- 2OWO chain A against the predicted model P15042: TM-score 0.47, RMSD 3.15 Å
- 2OWO chain A against the predicted model P15042: TM-score 0.47, RMSD 3.15 Å
Elsewhere
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