UniProt P14868
Aspartate--tRNA ligase, cytoplasmic (P14868)
Aspartate--tRNA ligase, cytoplasmic (UniProt P14868): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14868
- Protein
- Aspartate--tRNA ligase, cytoplasmic
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 1 record with a druggable one
Structures
7 records of P14868 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4J15 | Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase… | x-ray diffraction | A, B | — | — |
| 4J15 | Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase… | x-ray diffraction | A, B | — | — |
| 5Y6L | A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric… | x-ray diffraction | E | — | — |
| 5Y6L | A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric… | x-ray diffraction | E | — | — |
| 6IY6 | Crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) in complex with glutathion-S… | x-ray diffraction | A, B, G, H | ZN, PO4 | — |
| 6IY6 | Crystal structure of human cytosolic aspartyl-tRNA synthetase (drs) in complex with glutathion-S… | x-ray diffraction | A, B, G, H | ZN, PO4 | — |
| P14868 | AlphaFold monomer V2.0 prediction for aspartate--tRNA ligase, cytoplasmic (P14868) | predicted | A | — | 7 (best 0.72) |
Ligands
Experiment against prediction
- 4J15 chain B against the predicted model P14868: TM-score 0.99, RMSD 0.93 Å
- 4J15 chain B against the predicted model P14868: TM-score 0.99, RMSD 0.93 Å
- 4J15 chain A against the predicted model P14868: TM-score 0.98, RMSD 0.97 Å
- 4J15 chain A against the predicted model P14868: TM-score 0.98, RMSD 0.97 Å
- 6IY6 chain B against the predicted model P14868: TM-score 0.98, RMSD 1.14 Å
- 6IY6 chain B against the predicted model P14868: TM-score 0.98, RMSD 1.14 Å
- 6IY6 chain A against the predicted model P14868: TM-score 0.98, RMSD 1.19 Å
- 6IY6 chain A against the predicted model P14868: TM-score 0.98, RMSD 1.19 Å
- 6IY6 chain G against the predicted model P14868: TM-score 0.98, RMSD 1.27 Å
- 6IY6 chain G against the predicted model P14868: TM-score 0.98, RMSD 1.27 Å
Elsewhere
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