UniProt P12319
High affinity immunoglobulin epsilon receptor subunit alpha (P12319)
High affinity immunoglobulin epsilon receptor subunit alpha (UniProt P12319): 23 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against…
- UniProt
- P12319
- Protein
- High affinity immunoglobulin epsilon receptor subunit alpha
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 6 records with a druggable one
Structures
24 records of P12319 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F2Q | Crystal structure of the human high-affinity IgE receptor | x-ray diffraction | A | — | — |
| 1F2Q | Crystal structure of the human high-affinity IgE receptor | x-ray diffraction | A | — | — |
| 1F6A | Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha) | x-ray diffraction | A | — | — |
| 1F6A | Structure of the human IgE-Fc bound to its high affinity receptor FC(EPSILON)RI(ALPHA) | x-ray diffraction | A | — | — |
| 1J86 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), monoclinic crystal form 2 | x-ray diffraction | A, B | — | — |
| 1J86 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), monoclinic crystal form 2 | x-ray diffraction | A, B | — | — |
| 1J87 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), hexagonal crystal form 1 | x-ray diffraction | A | — | — |
| 1J87 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), hexagonal crystal form 1 | x-ray diffraction | A | — | — |
| 1J88 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), tetragonal crystal form 1 | x-ray diffraction | A, B, C, D, E | — | — |
| 1J88 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), tetragonal crystal form 1 | x-ray diffraction | A, B, C, D, E | — | — |
| 1J89 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), tetragonal crystal form 2 | x-ray diffraction | A, B, C, D, E | — | — |
| 1J89 | Human high affinity Fc receptor FC(EPSILON)RI(ALPHA), tetragonal crystal form 2 | x-ray diffraction | A, B, C, D, E | — | — |
| 1RPQ | High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from… | x-ray diffraction | A, B, C, D | — | — |
| 1RPQ | High affinity IgE receptor (alpha chain) complexed with tight-binding E131 'zeta' peptide from… | x-ray diffraction | A, B, C, D | — | — |
| 2Y7Q | The high-affinity complex between IgE and its receptor Fc epsilon ri | x-ray diffraction | A | — | — |
| 2Y7Q | The high-affinity complex between IgE and its receptor Fc epsilon ri | x-ray diffraction | A | — | — |
| 7SHT | Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant | electron microscopy | A | NAG | 4 (best 0.81) |
| 7SHT | Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant | electron microscopy | A | NAG | — |
| 8K7R | Human Fc epsilon RI in complex with hIgE Fc (TMD disordered) | electron microscopy | A | NAG, FUC, BMA, MAN | 2 (best 0.75) |
| 8YWA | The structure of IgE receptor binding to IgE | electron microscopy | A | NAG | 4 (best 0.72) |
| 8Z0T | Structure of the human ige-fc bound to its high affinity receptor fc(epsilon) | electron microscopy | A | NAG, BMA | 2 (best 0.71) |
| 9EQ3 | Structure of IgE HMM5 bound to FceRIa cryo-EM class 8 | electron microscopy | R | NAG, MAN | 3 (best 0.75) |
| 9EQ4 | Structure of IgE HMM5 bound to FceRIa cryo-EM class 5 | electron microscopy | R | NAG, MAN | 2 (best 0.72) |
| P12319 | AlphaFold monomer V2.0 prediction for high affinity immunoglobulin epsilon receptor subunit alpha… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8Z0T chain A against the predicted model P12319: TM-score 0.98, RMSD 0.78 Å
- 1RPQ chain C against the predicted model P12319: TM-score 0.98, RMSD 0.86 Å
- 1RPQ chain C against the predicted model P12319: TM-score 0.98, RMSD 0.86 Å
- 1RPQ chain A against the predicted model P12319: TM-score 0.98, RMSD 0.88 Å
- 1RPQ chain A against the predicted model P12319: TM-score 0.98, RMSD 0.88 Å
- 1RPQ chain B against the predicted model P12319: TM-score 0.97, RMSD 0.89 Å
- 1RPQ chain B against the predicted model P12319: TM-score 0.97, RMSD 0.89 Å
- 1J86 chain B against the predicted model P12319: TM-score 0.97, RMSD 0.94 Å
- 1J86 chain B against the predicted model P12319: TM-score 0.97, RMSD 0.94 Å
- 1RPQ chain D against the predicted model P12319: TM-score 0.97, RMSD 1.11 Å
Elsewhere
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