UniProt P11926
Ornithine decarboxylase (P11926)
Ornithine decarboxylase (UniProt P11926), EC 4.1.1.17: 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P11926
- Protein
- Ornithine decarboxylase
- EC
- 4.1.1.17
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 50 · 3 records with a druggable one
Structures
14 records of P11926 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D7K | Crystal structure of human ornithine decarboxylase at 2.1 ångströms resolution | x-ray diffraction | A, B | — | — |
| 1D7K | Crystal structure of human ornithine decarboxylase at 2.1 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2ON3 | A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases… | x-ray diffraction | A, B | — | — |
| 2ON3 | A structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases… | x-ray diffraction | A, B | — | — |
| 2OO0 | A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases… | x-ray diffraction | A, B | — | — |
| 2OO0 | A structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases… | x-ray diffraction | A, B | — | — |
| 4ZGY | Structure of human ornithine decarboxylase in complex with a C- terminal fragment of antizyme | x-ray diffraction | A | — | — |
| 5BWA | Crystal structure of odc-plp-AZ1 ternary complex | x-ray diffraction | A | — | — |
| 7S3F | Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its… | x-ray diffraction | A, B | PLP, XAP | 16 (best 0.80) |
| 7S3F | Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its… | x-ray diffraction | A, B | PLP, XAP | — |
| 7S3G | Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with… | x-ray diffraction | A, B | PLP | 17 (best 0.75) |
| 7S3G | Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with… | x-ray diffraction | A, B | PLP | — |
| 7U6U | Structure of an intellectual disability-associated ornithine decarboxylase variant G84R in complex… | x-ray diffraction | A, B | PLP | 17 (best 0.80) |
| P11926 | AlphaFold monomer V2.0 prediction for ornithine decarboxylase (P11926) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2ON3 chain A against the predicted model P11926: TM-score 0.99, RMSD 0.62 Å
- 2ON3 chain A against the predicted model P11926: TM-score 0.99, RMSD 0.62 Å
- 2ON3 chain B against the predicted model P11926: TM-score 0.99, RMSD 0.64 Å
- 2ON3 chain B against the predicted model P11926: TM-score 0.99, RMSD 0.64 Å
- 7S3F chain A against the predicted model P11926: TM-score 0.98, RMSD 1.25 Å
- 7S3F chain A against the predicted model P11926: TM-score 0.98, RMSD 1.25 Å
- 7S3F chain B against the predicted model P11926: TM-score 0.98, RMSD 1.28 Å
- 7S3F chain B against the predicted model P11926: TM-score 0.98, RMSD 1.28 Å
- 7U6U chain A against the predicted model P11926: TM-score 0.98, RMSD 1.29 Å
- 7U6U chain B against the predicted model P11926: TM-score 0.98, RMSD 1.39 Å
Elsewhere
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