UniProt P10613

Lanosterol 14-alpha demethylase (P10613)

Lanosterol 14-alpha demethylase (UniProt P10613), EC 1.14.13.70: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P10613
Protein: Lanosterol 14-alpha demethylase
EC: 1.14.13.70
Experimental structures: 2
Predicted models: 1
Ligands: 2
Pockets: 4 · 1 record with a druggable one

Structures

3 records of P10613 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5V5Z	Structure of CYP51 from the pathogen Candida albicans	x-ray diffraction	A	HEM, 1YN	4 (best 0.88)
5V5Z	Structure of CYP51 from the pathogen candida albicans	x-ray diffraction	A	HEM, 1YN	—
P10613	AlphaFold monomer V2.0 prediction for lanosterol 14-alpha demethylase (P10613)	predicted	A	—	—

Ligands

1YN · 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one · in 2 records
HEM · Protoporphyrin IX containing Fe · in 2 records

Experiment against prediction

5V5Z chain A against the predicted model P10613: TM-score 0.99, RMSD 0.64 Å
5V5Z chain A against the predicted model P10613: TM-score 0.99, RMSD 0.64 Å

Elsewhere

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