UniProt P10547
Lysostaphin (P10547)
Lysostaphin (UniProt P10547), EC 3.4.24.75: 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P10547
- Protein
- Lysostaphin
- EC
- 3.4.24.75
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 2 · 1 record with a druggable one
Structures
14 records of P10547 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4LXC | The antimicrobial peptidase lysostaphin from Staphylococcus simulans | x-ray diffraction | A, B, C, D | — | — |
| 4LXC | The antimicrobial peptidase lysostaphin from staphylococcus simulans | x-ray diffraction | A, B, C, D | — | — |
| 4QP5 | Catalytic domain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans… | x-ray diffraction | A, B | — | — |
| 4QP5 | Catalytic domain of the antimicrobial peptidase lysostaphin from staphylococcus simulans… | x-ray diffraction | A, B | — | — |
| 4QPB | Catalytic domain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans… | x-ray diffraction | A, B | — | — |
| 4QPB | Catalytic domain of the antimicrobial peptidase lysostaphin from staphylococcus simulans… | x-ray diffraction | A, B | — | — |
| 5LEO | Complex structure of lysostaphin SH3b domain with peptidoglycan fragment | x-ray diffraction | A, B | SO4 | 2 (best 0.63) |
| 5LEO | Complex structure of lysostaphin SH3B domain with peptidoglycan fragment | x-ray diffraction | A, B | SO4 | — |
| 5NMY | NMR solution structure of lysostaphin | solution nmr | A | ZN | — |
| 5NMY | NMR solution structure of lysostaphin | solution nmr | A | ZN | — |
| 6RJE | Lysostaphin SH3B P4-G5 complex, homesource dataset | x-ray diffraction | A | K5T | — |
| 6RK4 | Lysostaphin SH3b P4-G5 complex, synchrotron dataset | x-ray diffraction | A | K5T | — |
| 6RK4 | Lysostaphin SH3B P4-G5 complex, synchrotron dataset | x-ray diffraction | A | K5T | — |
| P10547 | AlphaFold monomer V2.0 prediction for lysostaphin (P10547) | predicted | A | — | — |
Ligands
- K5T · (2~{R})-2-[[(2~{S})-2-[[(4~{R})-5-azanyl-4-[[(2~{S})-2-azanylpropanoyl]amino]-5-oxidanylidene-pentanoyl]amino]-6-[2-[2-[2-[2-(2-azanylethanoylamino) ethanoylamino]ethanoylamino]ethanoylamino]ethanoylamin o]hexanoyl]amino]propanoic acid · in 3 records
- SO4 · Sulfate ion · in 2 records
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 4QPB chain A against the predicted model P10547: TM-score 0.99, RMSD 0.36 Å
- 4QPB chain A against the predicted model P10547: TM-score 0.99, RMSD 0.36 Å
- 4QP5 chain B against the predicted model P10547: TM-score 0.99, RMSD 0.36 Å
- 4QP5 chain B against the predicted model P10547: TM-score 0.99, RMSD 0.36 Å
- 4QP5 chain A against the predicted model P10547: TM-score 0.99, RMSD 0.49 Å
- 4QP5 chain A against the predicted model P10547: TM-score 0.99, RMSD 0.49 Å
- 4QPB chain B against the predicted model P10547: TM-score 0.99, RMSD 0.49 Å
- 4QPB chain B against the predicted model P10547: TM-score 0.99, RMSD 0.49 Å
- 6RK4 chain A against the predicted model P10547: TM-score 0.99, RMSD 0.39 Å
- 6RK4 chain A against the predicted model P10547: TM-score 0.99, RMSD 0.39 Å
Elsewhere
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