UniProt P10515
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (UniProt P10515): 23 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and…
- UniProt
- P10515
- Protein
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate…
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
24 records of P10515 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FYC | Inner lipoyl domain from human pyruvate dehydrogenase (pdh) complex, NMR, 1 structure | solution nmr | A | — | — |
| 1FYC | Inner lipoyl domain from human pyruvate dehydrogenase (pdh) complex, NMR, 1 structure | solution nmr | A | — | — |
| 1Y8N | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 1Y8N | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 1Y8O | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 1Y8O | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 1Y8P | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 1Y8P | Crystal structure of the PDK3-L2 complex | x-ray diffraction | B | — | — |
| 2DNE | Solution Structure of RSGI RUH-058, a lipoyl domain of human 2-oxoacid dehydrogenase | solution nmr | A | — | — |
| 2DNE | Solution structure of rsgi ruh-058, a lipoyl domain of human 2-oxoacid dehydrogenase | solution nmr | A | — | — |
| 2PNR | Crystal Structure of the asymmetric Pdk3-l2 Complex | x-ray diffraction | C, G | — | — |
| 2PNR | Crystal structure of the asymmetric PDK3-L2 complex | x-ray diffraction | C, G | — | — |
| 2Q8I | Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol | x-ray diffraction | B | — | — |
| 2Q8I | Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol | x-ray diffraction | B | — | — |
| 3B8K | Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2) | electron microscopy | A | — | — |
| 3B8K | Structure of the truncated human dihydrolipoyl acetyltransferase (E2) | electron microscopy | A | — | — |
| 3CRK | Crystal structure of the PDHK2-L2 complex. | x-ray diffraction | C, D | — | — |
| 3CRK | Crystal structure of the PDHK2-L2 complex. | x-ray diffraction | C, D | — | — |
| 3CRL | Crystal structure of the PDHK2-L2 complex. | x-ray diffraction | C, D | — | — |
| 3CRL | Crystal structure of the PDHK2-L2 complex. | x-ray diffraction | C, D | — | — |
| 6CT0 | Atomic structure of the E2 inner core of human pyruvate dehydrogenase complex | electron microscopy | 0 | — | — |
| 6H55 | core of the human pyruvate dehydrogenase (E2) | electron microscopy | A | — | — |
| 6H55 | Core of the human pyruvate dehydrogenase (E2) | electron microscopy | A | — | — |
| P10515 | AlphaFold monomer V2.0 prediction for dihydrolipoyllysine-residue acetyltransferase component of… | predicted | A | — | 3 (best 0.65) |
Experiment against prediction
- 3CRK chain D against the predicted model P10515: TM-score 0.98, RMSD 0.46 Å
- 3CRK chain D against the predicted model P10515: TM-score 0.98, RMSD 0.46 Å
- 2Q8I chain B against the predicted model P10515: TM-score 0.98, RMSD 0.54 Å
- 2Q8I chain B against the predicted model P10515: TM-score 0.98, RMSD 0.54 Å
- 6CT0 chain 0 against the predicted model P10515: TM-score 0.98, RMSD 0.99 Å
- 2PNR chain C against the predicted model P10515: TM-score 0.97, RMSD 0.55 Å
- 2PNR chain C against the predicted model P10515: TM-score 0.97, RMSD 0.55 Å
- 3CRK chain C against the predicted model P10515: TM-score 0.96, RMSD 0.69 Å
- 3CRK chain C against the predicted model P10515: TM-score 0.96, RMSD 0.69 Å
- 6H55 chain A against the predicted model P10515: TM-score 0.95, RMSD 1.37 Å
Elsewhere
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