UniProt P10378
Enterobactin synthase component E (P10378)
Enterobactin synthase component E (UniProt P10378), EC 6.2.1.71, 6.3.2.14: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P10378
- Protein
- Enterobactin synthase component E
- EC
- 6.2.1.71, 6.3.2.14
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 2 records with a druggable one
Structures
7 records of P10378 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RG2 | Structure of a two-domain NRPS fusion protein containing the EntE adenylation domain and EntB… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3RG2 | Structure of a two-domain nrps fusion protein containing the ente adenylation domain and entb… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4IZ6 | Structure of EntE and EntB, an NRPS adenylation-PCP fusion protein with pseudo translational… | x-ray diffraction | A, B | — | — |
| 4IZ6 | Structure of ente and entb, an nrps adenylation-pcp fusion protein with pseudo translational… | x-ray diffraction | A, B | — | — |
| 8K5S | The structure of EntE with 3-(prop-2-yn-1-yloxy)benzoic acid sulfamoyl adenosine | x-ray diffraction | A, B | VPT | 8 (best 0.80) |
| 8K5T | The structure of EntE with2-methyl-3-chloro-benzoic acid sulfamoyl adenosine | x-ray diffraction | A, B | VQ5 | 9 (best 0.79) |
| P10378 | AlphaFold monomer V2.0 prediction for enterobactin synthase component E (P10378) | predicted | A | — | — |
Ligands
- VPT · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-(3-prop-2-ynoxyphenyl)carbonylsulfamate · in 1 record
- VQ5 · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-(3-chloranyl-2-methyl-phenyl)carbonylsulfamate · in 1 record
Experiment against prediction
- 8K5S chain B against the predicted model P10378: TM-score 1.00, RMSD 0.37 Å
- 8K5T chain B against the predicted model P10378: TM-score 1.00, RMSD 0.38 Å
- 8K5T chain A against the predicted model P10378: TM-score 1.00, RMSD 0.48 Å
- 8K5S chain A against the predicted model P10378: TM-score 1.00, RMSD 0.54 Å
- 3RG2 chain C against the predicted model P10378: TM-score 0.86, RMSD 1.23 Å
- 3RG2 chain C against the predicted model P10378: TM-score 0.86, RMSD 1.23 Å
- 3RG2 chain A against the predicted model P10378: TM-score 0.86, RMSD 1.20 Å
- 3RG2 chain A against the predicted model P10378: TM-score 0.86, RMSD 1.20 Å
- 3RG2 chain F against the predicted model P10378: TM-score 0.87, RMSD 1.26 Å
- 3RG2 chain F against the predicted model P10378: TM-score 0.87, RMSD 1.26 Å
Elsewhere
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