UniProt P0DSP4
Cyclic AMP-AMP-GMP synthase (P0DSP4)
Cyclic AMP-AMP-GMP synthase (UniProt P0DSP4), EC 2.7.7.-: 11 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P0DSP4
- Protein
- Cyclic AMP-AMP-GMP synthase
- EC
- 2.7.7.-
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 17 · 3 records with a druggable one
Structures
12 records of P0DSP4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7D48 | apo-form cyclic trinucleotide synthase CdnD | x-ray diffraction | A | NA | 2 (best 0.71) |
| 7D48 | Apo-form cyclic trinucleotide synthase cdnd | x-ray diffraction | A | NA | — |
| 7D4J | Ddatp complex of cyclic trinucleotide synthase cdnd | x-ray diffraction | A | DDS, MG | — |
| 7D4O | cyclic trinucleotide synthase CdnD in complex with ATP and ADP | x-ray diffraction | A, B | ATP, ADP, MG | 8 (best 0.73) |
| 7D4O | Cyclic trinucleotide synthase cdnd in complex with ATP and ADP | x-ray diffraction | A, B | ATP, ADP, MG | — |
| 7D4S | Apo-form cyclic trinucleotide synthase cdnd | x-ray diffraction | A | APC, MG | — |
| 7D4U | ATP complex with double mutant cyclic trinucleotide synthase cdnd | x-ray diffraction | A | ATP | — |
| 7LJL | Structure of the Enterobacter cloacae CD-NTase CdnD in complex with ATP | x-ray diffraction | A, B | MG, ATP | 5 (best 0.78) |
| 7LJL | Structure of the enterobacter cloacae CD-ntase cdnd in complex with ATP | x-ray diffraction | A, B | MG, ATP | — |
| 7TQD | Structure of Enterobacter cloacae Cap2-CdnD02 2:1 complex | electron microscopy | C | AMP, MG, ATP, ADP | — |
| 7TSX | Structure of Enterobacter cloacae Cap2 bound to CdnD02 C-terminus, Apo state | x-ray diffraction | C, D | — | 2 (best 0.39) |
| P0DSP4 | AlphaFold monomer V2.0 prediction for cyclic AMP-AMP-gmp synthase (P0DSP4) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 7 records
- ATP · Adenosine-5'-triphosphate · in 6 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- NA · Sodium ion · in 2 records
- AMP · Adenosine monophosphate · in 1 record
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 1 record
- DDS · 2',3'-dideoxyadenosine triphosphate · in 1 record
Experiment against prediction
- 7D4J chain A against the predicted model P0DSP4: TM-score 0.99, RMSD 0.64 Å
- 7D4U chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 0.90 Å
- 7D48 chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 1.19 Å
- 7D48 chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 1.19 Å
- 7D4S chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 1.04 Å
- 7D4O chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 1.04 Å
- 7D4O chain A against the predicted model P0DSP4: TM-score 0.98, RMSD 1.04 Å
- 7D4O chain B against the predicted model P0DSP4: TM-score 0.98, RMSD 1.10 Å
- 7D4O chain B against the predicted model P0DSP4: TM-score 0.98, RMSD 1.10 Å
- 7LJL chain A against the predicted model P0DSP4: TM-score 0.97, RMSD 1.20 Å
Elsewhere
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