UniProt P0AFG8
Pyruvate dehydrogenase E1 component (P0AFG8)
Pyruvate dehydrogenase E1 component (UniProt P0AFG8): 12 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AFG8
- Protein
- Pyruvate dehydrogenase E1 component
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
13 records of P0AFG8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G25 | E. Coli Pyruvate Dehydrogenase Phosphonolactylthiamin Diphosphate Complex | x-ray diffraction | A, B | — | — |
| 2G25 | E. COLI pyruvate dehydrogenase phosphonolactylthiamin diphosphate complex | x-ray diffraction | A, B | — | — |
| 2G28 | E. Coli Pyruvate Dehydrogenase H407A variant Phosphonolactylthiamin Diphosphate Complex | x-ray diffraction | A, B | — | — |
| 2G28 | E. COLI pyruvate dehydrogenase H407A variant phosphonolactylthiamin diphosphate complex | x-ray diffraction | A, B | — | — |
| 2G67 | E. Coli Pyruvate Dehydrogenase E1 Component (Apoenzyme) | x-ray diffraction | A, B | — | — |
| 2G67 | E. COLI pyruvate dehydrogenase E1 component (apoenzyme) | x-ray diffraction | A, B | — | — |
| 2IEA | E. coli pyruvate dehydrogenase | x-ray diffraction | A, B | — | — |
| 2IEA | E. COLI pyruvate dehydrogenase | x-ray diffraction | A, B | — | — |
| 2QTA | E. coli Pyruvate dehydrogenase E1 component E401K mutant with thiamin diphosphate | x-ray diffraction | A, B | — | — |
| 2QTA | E. COLI pyruvate dehydrogenase E1 component E401K mutant with thiamin diphosphate | x-ray diffraction | A, B | — | — |
| 2QTC | E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate | x-ray diffraction | A, B | — | — |
| 2QTC | E. COLI pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate | x-ray diffraction | A, B | — | — |
| P0AFG8 | AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component (P0AFG8) | predicted | A | — | 5 (best 0.71) |
Experiment against prediction
- 2QTC chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.32 Å
- 2QTC chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.32 Å
- 2IEA chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.33 Å
- 2IEA chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.33 Å
- 2QTA chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.34 Å
- 2QTA chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.34 Å
- 2G28 chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.39 Å
- 2G28 chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.39 Å
- 2G67 chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.46 Å
- 2G67 chain A against the predicted model P0AFG8: TM-score 1.00, RMSD 0.46 Å
Elsewhere
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