UniProt P0AEE8
DNA adenine methylase (P0AEE8)
DNA adenine methylase (UniProt P0AEE8), EC 2.1.1.72: 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AEE8
- Protein
- DNA adenine methylase
- EC
- 2.1.1.72
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 9 · 2 records with a druggable one
Structures
15 records of P0AEE8 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G1P | Structure of E. coli DNA adenine methyltransferase (DAM) | x-ray diffraction | A, B | SAH | 3 (best 0.73) |
| 2G1P | Structure of E. COLI DNA adenine methyltransferase (dam) | x-ray diffraction | A, B | — | — |
| 2ORE | Binary Structure of Escherichia coli DNA Adenine Methyltransferase and S-adenosylhomocysteine | x-ray diffraction | D, E, F | SAH, SO4 | 6 (best 0.62) |
| 2ORE | Binary structure of escherichia COLI DNA adenine methyltransferase and S-adenosylhomocysteine | x-ray diffraction | D, E, F | — | — |
| 4GBE | Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with SAH | x-ray diffraction | D, E, F | — | — |
| 4GBE | Crystal structure of E. COLI DNA adenine methyltransferase in complex with sah | x-ray diffraction | D, E, F | — | — |
| 4GOL | Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Methylated Aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GOL | Crystal structure of E. COLI DNA adenine methyltransferase in complex with methylated aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GOM | Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GOM | Crystal structure of E. COLI DNA adenine methyltransferase in complex with aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GON | Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GON | Crystal structure of E. COLI DNA adenine methyltransferase in complex with indole aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GOO | Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Benzothiophene Aza-SAM | x-ray diffraction | D, E, F | — | — |
| 4GOO | Crystal structure of E. COLI DNA adenine methyltransferase in complex with benzothiophene aza-SAM | x-ray diffraction | D, E, F | — | — |
| P0AEE8 | AlphaFold monomer V2.0 prediction for DNA adenine methylase (P0AEE8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2G1P chain A against the predicted model P0AEE8: TM-score 1.00, RMSD 0.30 Å
- 2G1P chain B against the predicted model P0AEE8: TM-score 1.00, RMSD 0.33 Å
- 2ORE chain F against the predicted model P0AEE8: TM-score 0.99, RMSD 0.42 Å
- 2ORE chain E against the predicted model P0AEE8: TM-score 0.99, RMSD 0.43 Å
- 2G1P chain A against the predicted model P0AEE8: TM-score 0.99, RMSD 0.30 Å
- 2G1P chain B against the predicted model P0AEE8: TM-score 0.99, RMSD 0.33 Å
- 2ORE chain D against the predicted model P0AEE8: TM-score 0.99, RMSD 0.50 Å
- 2ORE chain F against the predicted model P0AEE8: TM-score 0.99, RMSD 0.42 Å
- 2ORE chain E against the predicted model P0AEE8: TM-score 0.99, RMSD 0.43 Å
- 4GBE chain E against the predicted model P0AEE8: TM-score 0.99, RMSD 0.44 Å
Elsewhere
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