UniProt P0ACK0
cAMP-activated global transcriptional regulator CRP (P0ACK0)
cAMP-activated global transcriptional regulator CRP (UniProt P0ACK0): 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0ACK0
- Protein
- cAMP-activated global transcriptional regulator CRP
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 3 records with a druggable one
Structures
10 records of P0ACK0 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WC2 | Nmr structure of catabolite activator protein in the unliganded state | solution nmr | A, B | — | — |
| 2WC2 | NMR structure of catabolite activator protein in the unliganded state | solution nmr | A, B | — | — |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | G, H | CMP | 2 (best 0.86) |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | G, H | CMP | — |
| 6PB4 | The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | G, H | CMP | 2 (best 0.83) |
| 6PB4 | The E. COLI class-II cap-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | G, H | CMP | — |
| 6PB5 | The E. COLI class-II cap-dependent transcription activation complex at the state 1 architecture | electron microscopy | G, H | CMP | — |
| 6PB6 | The E. coli class-II CAP-dependent transcription activation complex at the state 2 | electron microscopy | G, H | CMP | 2 (best 0.83) |
| 6PB6 | The E. COLI class-II cap-dependent transcription activation complex at the state 2 | electron microscopy | G, H | CMP | — |
| P0ACK0 | AlphaFold monomer V2.0 prediction for camp-activated global transcriptional regulator crp (P0ACK0) | predicted | A | — | — |
Ligands
- CMP · Adenosine-3',5'-cyclic-monophosphate · in 7 records
Experiment against prediction
- 6B6H chain G against the predicted model P0ACK0: TM-score 0.96, RMSD 1.13 Å
- 6B6H chain G against the predicted model P0ACK0: TM-score 0.96, RMSD 1.13 Å
- 6B6H chain H against the predicted model P0ACK0: TM-score 0.95, RMSD 1.26 Å
- 6B6H chain H against the predicted model P0ACK0: TM-score 0.95, RMSD 1.26 Å
- 6PB4 chain G against the predicted model P0ACK0: TM-score 0.92, RMSD 1.53 Å
- 6PB4 chain G against the predicted model P0ACK0: TM-score 0.92, RMSD 1.53 Å
- 6PB5 chain G against the predicted model P0ACK0: TM-score 0.91, RMSD 1.68 Å
- 6PB6 chain G against the predicted model P0ACK0: TM-score 0.91, RMSD 1.71 Å
- 6PB6 chain G against the predicted model P0ACK0: TM-score 0.91, RMSD 1.71 Å
- 6PB6 chain H against the predicted model P0ACK0: TM-score 0.89, RMSD 2.00 Å
Elsewhere
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