UniProt P0AC47
Fumarate reductase iron-sulfur protein (P0AC47)
Fumarate reductase iron-sulfur protein (UniProt P0AC47), EC 1.3.99.1: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 104 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0AC47
- Protein
- Fumarate reductase iron-sulfur protein
- EC
- 1.3.99.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 104 · 8 records with a druggable one
Structures
9 records of P0AC47 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KF6 | E. coli Quinol-Fumarate Reductase with Bound Inhibitor HQNO | x-ray diffraction | B, N | FES, F3S, SF4, HQO, CE1 | 14 (best 0.85) |
| 1KF6 | E. COLI quinol-fumarate reductase with bound inhibitor hqno | x-ray diffraction | B, N | FES, F3S, SF4, HQO, CE1 | 14 (best 0.85) |
| 1KFY | Quinol-fumarate reductase with quinol inhibitor 2-[1-(4-chloro-phenyl)-ethyl]-4,6-dinitro-phenol | x-ray diffraction | B, N | FES, F3S, SF4, BRS, CE1 | 13 (best 0.85) |
| 1KFY | Quinol-fumarate reductase with quinol inhibitor 2-[1-(4-chloro- phenyl)-ethyl]-4,6-dinitro-phenol | x-ray diffraction | B, N | FES, F3S, SF4, BRS, CE1 | 13 (best 0.85) |
| 1L0V | Quinol-Fumarate Reductase with Menaquinol Molecules | x-ray diffraction | B, N | FES, F3S, SF4, MQ7, CE1 | 12 (best 0.87) |
| 1L0V | Quinol-fumarate reductase with menaquinol molecules | x-ray diffraction | B, N | FES, F3S, SF4, MQ7, CE1 | 12 (best 0.87) |
| 3CIR | E. coli Quinol fumarate reductase FrdA T234A mutation | x-ray diffraction | B, N | FES, F3S, SF4 | 13 (best 0.83) |
| 3CIR | E. COLI quinol fumarate reductase frda T234A mutation | x-ray diffraction | B, N | FES, F3S, SF4 | 13 (best 0.83) |
| P0AC47 | AlphaFold monomer V2.0 prediction for fumarate reductase iron-sulfur subunit (P0AC47) | predicted | A | — | — |
Ligands
- F3S · FE3-S4 cluster · in 8 records
- FES · Fe2/s2 (inorganic) cluster · in 8 records
- SF4 · Iron/sulfur cluster · in 8 records
- CE1 · O-dodecanyl octaethylene glycol · in 6 records
- BRS · 2-[1-(4-chloro-phenyl)-ethyl]-4,6-dinitro-phenol · in 2 records
- HQO · 2-heptyl-4-hydroxy quinoline N-oxide · in 2 records
- MQ7 · Menaquinone-7 · in 2 records
Experiment against prediction
- 1KFY chain B against the predicted model P0AC47: TM-score 0.99, RMSD 0.71 Å
- 1KFY chain B against the predicted model P0AC47: TM-score 0.99, RMSD 0.71 Å
- 1KF6 chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.77 Å
- 1KF6 chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.77 Å
- 1KFY chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.78 Å
- 1KFY chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.78 Å
- 1KF6 chain B against the predicted model P0AC47: TM-score 0.99, RMSD 0.73 Å
- 1KF6 chain B against the predicted model P0AC47: TM-score 0.99, RMSD 0.73 Å
- 1L0V chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.80 Å
- 1L0V chain N against the predicted model P0AC47: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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