UniProt P0ABH9
ATP-dependent Clp protease ATP-binding subunit ClpA (P0ABH9)
ATP-dependent Clp protease ATP-binding subunit ClpA (UniProt P0ABH9): 37 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 132 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0ABH9
- Protein
- ATP-dependent Clp protease ATP-binding subunit ClpA
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 132 · 7 records with a druggable one
Structures
38 records of P0ABH9 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K6K | Crystal Structure of ClpA, an AAA+ Chaperone-like Regulator of ClpAP protease implication to the… | x-ray diffraction | A | — | — |
| 1K6K | Crystal structure of clpa, an aaa+ chaperone-like regulator of clpap protease implication to the… | x-ray diffraction | A | — | — |
| 1KSF | Crystal Structure of ClpA, an HSP100 chaperone and regulator of ClpAP protease: Structural basis of… | x-ray diffraction | X | — | — |
| 1KSF | Crystal structure of clpa, an HSP100 chaperone and regulator of clpap protease: structural basis of… | x-ray diffraction | X | — | — |
| 1LZW | Structural basis of ClpS-mediated switch in ClpA substrate recognition | x-ray diffraction | B | — | — |
| 1LZW | Structural basis of clps-mediated switch in clpa substrate recognition | x-ray diffraction | B | — | — |
| 1MBU | Crystal Structure Analysis of ClpSN heterodimer | x-ray diffraction | A, B | — | — |
| 1MBU | Crystal structure analysis of clpsn heterodimer | x-ray diffraction | A, B | — | — |
| 1MBV | CRYSTAL STRUCTURE ANALYSIS OF ClpSN HETERODIMER TETRAGONAL FORM | x-ray diffraction | A | — | — |
| 1MBV | Crystal structure analysis of clpsn heterodimer tetragonal form | x-ray diffraction | A | — | — |
| 1MBX | CRYSTAL STRUCTURE ANALYSIS OF ClpSN WITH TRANSITION METAL ION BOUND | x-ray diffraction | A, B | — | — |
| 1MBX | Crystal structure analysis of clpsn with transition metal ion bound | x-ray diffraction | A, B | — | — |
| 1MG9 | The structural basis of ClpS-mediated switch in ClpA substrate recognition | x-ray diffraction | B | — | — |
| 1MG9 | The structural basis of clps-mediated switch in clpa substrate recognition | x-ray diffraction | B | — | — |
| 1R6B | High resolution crystal structure of ClpA | x-ray diffraction | X | — | — |
| 1R6B | High resolution crystal structure of clpa | x-ray diffraction | X | — | — |
| 1R6C | High resolution structure of ClpN | x-ray diffraction | X | — | — |
| 1R6C | High resolution structure of clpn | x-ray diffraction | X | — | — |
| 1R6O | ATP-dependent Clp protease ATP-binding subunit clpA/ATP-dependent Clp protease adaptor protein clpS | x-ray diffraction | A, B | — | — |
| 1R6O | ATP-dependent clp protease ATP-binding subunit CLPA/ATP-dependent clp protease adaptor protein clps | x-ray diffraction | A, B | — | — |
| 1R6Q | ClpNS with fragments | x-ray diffraction | A, B | — | — |
| 1R6Q | Clpns with fragments | x-ray diffraction | A, B | — | — |
| 5OFO | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state… | electron microscopy | C, F, E, D, B, A | AGS | 20 (best 0.83) |
| 5OFO | Cryo EM structure of the E. COLI disaggregase clpb (bap form, dwb mutant), in the atpgammas state… | electron microscopy | C, F, E, D, B, A | AGS | — |
| 5OG1 | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state | electron microscopy | C, F, E, D, B, A | AGS | 20 (best 0.88) |
| 5OG1 | Cryo EM structure of the E. COLI disaggregase clpb (bap form, dwb mutant), in the atpgammas state | electron microscopy | C, F, E, D, B, A | AGS | — |
| 6W1Z | ClpAP Engaged1 State bound to RepA-GFP | electron microscopy | A, B, C, D, E, F | ATP, ADP | 16 (best 0.85) |
| 6W1Z | Clpap ENGAGED1 state bound to repa-GFP | electron microscopy | A, B, C, D, E, F | ATP, ADP | — |
| 6W20 | ClpAP Disengaged State bound to RepA-GFP | electron microscopy | A, B, C, D, E, F | ADP, ATP | 18 (best 0.85) |
| 6W20 | Clpap disengaged state bound to repa-GFP | electron microscopy | A, B, C, D, E, F | ADP, ATP | — |
| 6W21 | ClpAP Engaged2 State bound to RepA-GFP | electron microscopy | A, B, C, D, E, F | ADP, ATP | 18 (best 0.87) |
| 6W21 | Clpap ENGAGED2 state bound to repa-GFP | electron microscopy | A, B, C, D, E, F | ADP, ATP | — |
| 6W22 | Clpa ENGAGED1 state bound to repa-GFP (clpa focused refinement) | electron microscopy | A, B, C, D, E, F | ATP, ADP | — |
| 6W23 | ClpA Disengaged State bound to RepA-GFP (Focused Classification) | electron microscopy | A, B, C, D, E, F | ADP, ATP | 20 (best 0.86) |
| 6W23 | Clpa disengaged state bound to repa-GFP (focused classification) | electron microscopy | A, B, C, D, E, F | ADP, ATP | — |
| 6W24 | ClpA Engaged2 State bound to RepA-GFP (Focused Classification) | electron microscopy | A, B, C, D, E, F | ADP, ATP | 20 (best 0.85) |
| 6W24 | Clpa ENGAGED2 state bound to repa-GFP (focused classification) | electron microscopy | A, B, C, D, E, F | ADP, ATP | — |
| P0ABH9 | AlphaFold monomer V2.0 prediction for ATP-dependent clp protease ATP- binding subunit clpa (P0ABH9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1R6Q chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.48 Å
- 1R6Q chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.48 Å
- 1MBU chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.49 Å
- 1MBU chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.49 Å
- 1R6O chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.54 Å
- 1R6O chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.54 Å
- 1MBX chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.54 Å
- 1MBX chain B against the predicted model P0ABH9: TM-score 0.99, RMSD 0.54 Å
- 1MBV chain A against the predicted model P0ABH9: TM-score 0.98, RMSD 0.60 Å
- 1MBV chain A against the predicted model P0ABH9: TM-score 0.98, RMSD 0.60 Å
Elsewhere
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