UniProt P0ABE8
Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 (P0ABE8)
Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 (UniProt P0ABE8): 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 35 pockets. Binding sites, druggability and experiment against…
- UniProt
- P0ABE8
- Protein
- Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 35 · 2 records with a druggable one
Structures
3 records of P0ABE8 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 9DX7 | LRRC8A:D Conformation 1 | electron microscopy | C, A, B, D | PEE | 18 (best 0.80) |
| 9DXA | LRRC8A:D Conformation 2 | electron microscopy | A, B, C, D | PEE | 17 (best 0.81) |
| P0ABE8 | AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE8) | predicted | A | — | — |
Ligands
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 2 records
Experiment against prediction
- 9DX7 chain D against the predicted model Q80WG5: TM-score 0.97, RMSD 1.21 Å
- 9DX7 chain C against the predicted model Q80WG5: TM-score 0.97, RMSD 1.25 Å
- 9DXA chain A against the predicted model Q80WG5: TM-score 0.96, RMSD 1.31 Å
- 9DX7 chain A against the predicted model Q80WG5: TM-score 0.96, RMSD 1.32 Å
- 9DXA chain B against the predicted model Q80WG5: TM-score 0.96, RMSD 1.36 Å
- 9DX7 chain B against the predicted model P0ABE8: TM-score 0.26, RMSD 3.73 Å
- 9DXA chain D against the predicted model P0ABE8: TM-score 0.26, RMSD 3.80 Å
- 9DX7 chain D against the predicted model P0ABE8: TM-score 0.26, RMSD 3.70 Å
- 9DXA chain A against the predicted model P0ABE8: TM-score 0.26, RMSD 4.33 Å
- 9DXA chain B against the predicted model P0ABE8: TM-score 0.26, RMSD 4.29 Å
Elsewhere
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