UniProt P0AAI3
ATP-dependent zinc metalloprotease FtsH (P0AAI3)
ATP-dependent zinc metalloprotease FtsH (UniProt P0AAI3), EC 3.4.24.-: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0AAI3
- Protein
- ATP-dependent zinc metalloprotease FtsH
- EC
- 3.4.24.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 27 · 2 records with a druggable one
Structures
9 records of P0AAI3 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LV7 | Crystal Structure of the AAA domain of FtsH | x-ray diffraction | A | SO4 | 1 (best 0.44) |
| 1LV7 | Crystal structure of the aaa domain of ftsh | x-ray diffraction | A | — | — |
| 4V0B | Escherichia coli FtsH hexameric N-domain | x-ray diffraction | A, B, C | — | — |
| 4V0B | Escherichia COLI ftsh hexameric N-domain | x-ray diffraction | A, B, C | — | — |
| 7WI3 | Cryo-EM structure of E.Coli FtsH-HflkC AAA protease complex | electron microscopy | E, H, I, J, K, L, g, m, o, q, s, u, h, n, p, r, t, v, Q, T, U, V, W, X | — | 6 (best 0.77) |
| 7WI3 | Cryo-EM structure of E.COLI ftsh-hflkc aaa protease complex | electron microscopy | E, H, I, J, K, L, g, m, o, q, s, u, h, n, p, r, t, v, Q, T, U, V, W, X | — | — |
| 7WI4 | Cryo-EM structure of E.Coli FtsH protease cytosolic domains | electron microscopy | A, D, E, F, B, C | ANP, ZN, MG | 20 (best 0.82) |
| 7WI4 | Cryo-EM structure of E.COLI ftsh protease cytosolic domains | electron microscopy | A, D, E, F, B, C | ANP, ZN, MG | — |
| P0AAI3 | AlphaFold monomer V2.0 prediction for ATP-dependent zinc metalloprotease ftsh (P0AAI3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4V0B chain B against the predicted model P0AAI3: TM-score 0.98, RMSD 0.42 Å
- 4V0B chain B against the predicted model P0AAI3: TM-score 0.98, RMSD 0.42 Å
- 4V0B chain A against the predicted model P0AAI3: TM-score 0.98, RMSD 0.42 Å
- 4V0B chain A against the predicted model P0AAI3: TM-score 0.98, RMSD 0.42 Å
- 4V0B chain C against the predicted model P0AAI3: TM-score 0.98, RMSD 0.49 Å
- 4V0B chain C against the predicted model P0AAI3: TM-score 0.98, RMSD 0.49 Å
- 7WI4 chain B against the predicted model P0AAI3: TM-score 0.94, RMSD 1.89 Å
- 7WI4 chain B against the predicted model P0AAI3: TM-score 0.94, RMSD 1.89 Å
- 7WI4 chain C against the predicted model P0AAI3: TM-score 0.93, RMSD 1.90 Å
- 7WI4 chain C against the predicted model P0AAI3: TM-score 0.93, RMSD 1.90 Å
Elsewhere
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