UniProt P0AA89
Diguanylate cyclase DosC (P0AA89)
Diguanylate cyclase DosC (UniProt P0AA89), EC 2.7.7.65: 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AA89
- Protein
- Diguanylate cyclase DosC
- EC
- 2.7.7.65
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 9 · 1 record with a druggable one
Structures
15 records of P0AA89 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZVA | Crystal structure of globin domain of the E. coli DosC - form I (ferric) | x-ray diffraction | A, B | — | — |
| 4ZVA | Crystal structure of globin domain of the E. COLI dosc - form I (ferric) | x-ray diffraction | A, B | — | — |
| 4ZVB | Crystal structure of globin domain of the E. coli DosC - form II (ferrous) | x-ray diffraction | A, B, C, D | HEM | 9 (best 0.80) |
| 4ZVB | Crystal structure of globin domain of the E. COLI dosc - form II (ferrous) | x-ray diffraction | A, B, C, D | — | — |
| 4ZVC | Crystal structure of MID domain of the E. coli DosC - form I | x-ray diffraction | A, B | — | — |
| 4ZVC | Crystal structure of mid domain of the E. COLI dosc - form I | x-ray diffraction | A, B | — | — |
| 4ZVD | Crystal structure of MID domain of the E. coli DosC - form II | x-ray diffraction | A, B | — | — |
| 4ZVD | Crystal structure of mid domain of the E. COLI dosc - form II | x-ray diffraction | A, B | — | — |
| 4ZVE | Crystal structure of GGDEF domain of the E. coli DosC - form I (apo-form) | x-ray diffraction | A | — | — |
| 4ZVE | Crystal structure of ggdef domain of the E. COLI dosc - form I (apo- form) | x-ray diffraction | A | — | — |
| 4ZVF | Crystal structure of GGDEF domain of the E. coli DosC - form II (GTP-alpha-S-bound) | x-ray diffraction | A | — | — |
| 4ZVF | Crystal structure of ggdef domain of the E. COLI dosc - form II (GTP- alpha-S-bound) | x-ray diffraction | A | — | — |
| 4ZVG | Crystal structure of GGDEF domain of the E. coli DosC - form III | x-ray diffraction | A, B | — | — |
| 4ZVG | Crystal structure of ggdef domain of the E. COLI dosc - form III | x-ray diffraction | A, B | — | — |
| P0AA89 | AlphaFold monomer V2.0 prediction for diguanylate cyclase dosc (P0AA89) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 1 record
Experiment against prediction
- 4ZVB chain A against the predicted model P0AA89: TM-score 0.99, RMSD 0.41 Å
- 4ZVB chain A against the predicted model P0AA89: TM-score 0.99, RMSD 0.41 Å
- 4ZVB chain C against the predicted model P0AA89: TM-score 0.99, RMSD 0.43 Å
- 4ZVB chain C against the predicted model P0AA89: TM-score 0.99, RMSD 0.43 Å
- 4ZVA chain B against the predicted model P0AA89: TM-score 0.99, RMSD 0.46 Å
- 4ZVA chain B against the predicted model P0AA89: TM-score 0.99, RMSD 0.46 Å
- 4ZVA chain A against the predicted model P0AA89: TM-score 0.99, RMSD 0.47 Å
- 4ZVA chain A against the predicted model P0AA89: TM-score 0.99, RMSD 0.47 Å
- 4ZVB chain B against the predicted model P0AA89: TM-score 0.99, RMSD 0.51 Å
- 4ZVB chain B against the predicted model P0AA89: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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