UniProt P0A802
DNA-directed RNA polymerase subunit omega (P0A802)
DNA-directed RNA polymerase subunit omega (UniProt P0A802), EC 2.7.7.6: 47 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A802
- Protein
- DNA-directed RNA polymerase subunit omega
- EC
- 2.7.7.6
- Experimental structures
- 47
- Predicted models
- 1
- Pockets
- 2 · 2 records with a druggable one
Structures
48 records of P0A802 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YG2 | X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme | x-ray diffraction | E, K | — | — |
| 4YG2 | X-ray crystal structur of escherichia COLI RNA polymerase SIGMA70 holoenzyme | x-ray diffraction | E, K | — | — |
| 6GOV | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | electron microscopy | W | — | — |
| 6GOV | Structure of the RNA polymerase lambda-based antitermination complex | electron microscopy | W | — | — |
| 6N62 | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | E | — | — |
| 6N62 | Escherichia COLI RNA polymerase SIGMA70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | E | — | — |
| 6OMF | CryoEM structure of SigmaS-transcription initiation complex with activator Crl | electron microscopy | E | — | — |
| 6OMF | Cryoem structure of sigmas-transcription initiation complex with activator crl | electron microscopy | E | — | — |
| 6OUL | Cryo-EM structure of escherichia COLI rnap polymerase bound to RPSTP2 promoter DNA | electron microscopy | K | — | — |
| 6P1K | Cryo-EM structure of escherichia COLI SIGMA70 bound rnap polymerase holoenzyme | electron microscopy | K | — | — |
| 6PSQ | Escherichia COLI RNA polymerase closed complex (trpc) with trar and rpst P2 promoter | electron microscopy | K | — | — |
| 6PSR | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1) with trar and rpst P2… | electron microscopy | K | — | — |
| 6PSS | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1.5A) with trar and mutant… | electron microscopy | K | — | — |
| 6PST | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1.5B) with trar and mutant… | electron microscopy | K | — | — |
| 6PSU | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI2) with trar and rpst P2… | electron microscopy | K | — | — |
| 6PSV | Escherichia COLI RNA polymerase promoter unwinding intermediate (tprerpo) with trar and rpst P2… | electron microscopy | K | — | — |
| 6PSW | Escherichia COLI RNA polymerase promoter unwinding intermediate (trpo) with trar and rpst P2… | electron microscopy | K | — | — |
| 6VJS | Escherichia COLI RNA polymerase and ureidothiophene-2-carboxylic acid complex | x-ray diffraction | E, J | — | — |
| 6VYX | Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long… | electron microscopy | AF | — | — |
| 6VYZ | Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long… | electron microscopy | AF | — | — |
| 6VZ2 | Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long… | electron microscopy | AF | — | — |
| 6WMU | E. coli RNAPs70-SspA-gadA DNA complex | electron microscopy | E | — | — |
| 6WMU | E. COLI RNAPS70-sspa-gada DNA complex | electron microscopy | E | — | — |
| 6X26 | Mfd-bound E.COLI RNA polymerase elongation complex - L1 state | electron microscopy | K | — | — |
| 6X2F | Mfd-bound E.COLI RNA polymerase elongation complex - L2 state | electron microscopy | K | — | — |
| 6X2N | Mfd-bound E.COLI RNA polymerase elongation complex - I state | electron microscopy | K | — | — |
| 6X43 | Mfd-bound E.coli RNA polymerase elongation complex - II state | electron microscopy | K | — | — |
| 6X43 | Mfd-bound E.COLI RNA polymerase elongation complex - II state | electron microscopy | K | — | — |
| 6X4W | Mfd-bound E.COLI RNA polymerase elongation complex - III state | electron microscopy | K | — | — |
| 6X4Y | Mfd-bound E.COLI RNA polymerase elongation complex - IV state | electron microscopy | K | — | — |
| 6X50 | Mfd-bound E.COLI RNA polymerase elongation complex - V state | electron microscopy | K | — | — |
| 6X6T | Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1)… | electron microscopy | AF | — | — |
| 6X7F | Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2)… | electron microscopy | AF | — | — |
| 7M8E | E.coli RNAP-RapA elongation complex | electron microscopy | E | — | — |
| 7M8E | E.COLI rnap-rapa elongation complex | electron microscopy | E | — | — |
| 7MKD | Cryo-EM structure of escherichia COLI RNA polymerase bound to lambda pr promoter DNA (class 1) | electron microscopy | K | — | — |
| 7MKE | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) | electron microscopy | K | — | — |
| 7MKE | Cryo-EM structure of escherichia COLI RNA polymerase bound to lambda pr promoter DNA (class 2) | electron microscopy | K | — | — |
| 7MKI | Cryo-EM structure of escherichia COLI RNA polymerase bound to lambda pr (-5G to C) promoter DNA | electron microscopy | K | — | — |
| 7MKJ | Cryo-EM structure of escherichia COLI RNA polymerase bound to T7A1 promoter DNA | electron microscopy | K | — | — |
| 7N4E | Escherichia COLI sigma 70-dependent paused transcription elongation complex | electron microscopy | E | — | — |
| 8E5O | Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA… | electron microscopy | E | — | — |
| 8E6X | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA… | electron microscopy | E | — | — |
| 8EGB | Cryo-EM structure of consensus elemental paused elongation complex with an unfolded TL | electron microscopy | K | — | — |
| 8EH9 | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL… | electron microscopy | K | — | 1 (best 0.55) |
| 8EHA | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL… | electron microscopy | K | — | — |
| 8EHF | Cryo-EM structure of his-elemental paused elongation complex with an unfolded TL (1) | electron microscopy | K | — | 1 (best 0.58) |
| P0A802 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit omega (P0A802) | predicted | A | — | — |
Experiment against prediction
- 6PST chain K against the predicted model P0A802: TM-score 0.96, RMSD 0.78 Å
- 6PSS chain K against the predicted model P0A802: TM-score 0.96, RMSD 0.81 Å
- 8EHF chain K against the predicted model P0A802: TM-score 0.96, RMSD 0.90 Å
- 7N4E chain E against the predicted model P0A802: TM-score 0.95, RMSD 1.22 Å
- 6PSR chain K against the predicted model P0A802: TM-score 0.95, RMSD 0.88 Å
- 8E5O chain E against the predicted model P0A802: TM-score 0.95, RMSD 0.79 Å
- 8E6X chain E against the predicted model P0A802: TM-score 0.95, RMSD 0.79 Å
- 8EHA chain K against the predicted model P0A802: TM-score 0.95, RMSD 0.93 Å
- 6PSQ chain K against the predicted model P0A802: TM-score 0.95, RMSD 0.91 Å
- 6X43 chain K against the predicted model P0A802: TM-score 0.95, RMSD 0.98 Å
Elsewhere
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