UniProt P0A790
Aspartate 1-decarboxylase (P0A790)
Aspartate 1-decarboxylase (UniProt P0A790), EC 4.1.1.11: 36 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A790
- Protein
- Aspartate 1-decarboxylase
- EC
- 4.1.1.11
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 1 · 1 record with a druggable one
Structures
37 records of P0A790 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AW8 | Pyruvoyl dependent aspartate decarboxylase | x-ray diffraction | A, B, D, E | — | — |
| 1AW8 | Pyruvoyl dependent aspartate decarboxylase | x-ray diffraction | A, B, D, E | — | — |
| 1PPY | Native precursor of pyruvoyl dependent Aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PPY | Native precursor of pyruvoyl dependent aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PQE | S25A mutant of pyruvoyl dependent aspartate decarboxylase | x-ray diffraction | A | — | — |
| 1PQE | S25A mutant of pyruvoyl dependent aspartate decarboxylase | x-ray diffraction | A | — | — |
| 1PQF | Glycine 24 to Serine mutation of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PQF | Glycine 24 to serine mutation of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PQH | Serine 25 to Threonine mutation of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PQH | Serine 25 to threonine mutation of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 1PT0 | Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with an Alanine insertion at position 26 | x-ray diffraction | A, B | — | — |
| 1PT0 | Unprocessed pyruvoyl dependent aspartate decarboxylase with an alanine insertion at position 26 | x-ray diffraction | A, B | — | — |
| 1PT1 | Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with Histidine 11 Mutated to Alanine | x-ray diffraction | A, B | — | — |
| 1PT1 | Unprocessed pyruvoyl dependent aspartate decarboxylase with histidine 11 mutated to alanine | x-ray diffraction | A, B | — | — |
| 1PYQ | Unprocessed Aspartate Decarboxylase Mutant, with Alanine inserted at position 24 | x-ray diffraction | A, B | — | — |
| 1PYQ | Unprocessed aspartate decarboxylase mutant, with alanine inserted at position 24 | x-ray diffraction | A, B | — | — |
| 1PYU | Processed Aspartate Decarboxylase Mutant with Ser25 mutated to Cys | x-ray diffraction | A, B, C, D | — | — |
| 1PYU | Processed aspartate decarboxylase mutant with SER25 mutated to cys | x-ray diffraction | A, B, C, D | — | — |
| 3TM7 | Processed Aspartate Decarboxylase Mutant with Asn72 mutated to Ala | x-ray diffraction | A, B, C, D | — | — |
| 3TM7 | Processed aspartate decarboxylase mutant with ASN72 mutated to ala | x-ray diffraction | A, B, C, D | — | — |
| 4AOK | Conformational dynamics of aspartate alpha-decarboxylase active site revealed by protein-ligand… | x-ray diffraction | A, B, D, E | — | — |
| 4AOK | Conformational dynamics of aspartate alpha-decarboxylase active site revealed by protein-ligand… | x-ray diffraction | A, B, D, E | — | — |
| 4AON | Conformational dynamics of aspartate alpha-decarboxylase active site revealed by protein-ligand… | x-ray diffraction | A, B, D, E | — | — |
| 4AON | Conformational dynamics of aspartate alpha-decarboxylase active site revealed by protein-ligand… | x-ray diffraction | A, B, D, E | — | — |
| 4AZD | T57V mutant of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 4AZD | T57V mutant of aspartate decarboxylase | x-ray diffraction | A, B | — | — |
| 4CRY | Direct visualisation of strain-induced protein post-translational modification | x-ray diffraction | A, G | — | — |
| 4CRY | Direct visualisation of strain-induced protein post- translational modification | x-ray diffraction | A, G | — | — |
| 4CRZ | Direct visualisation of strain-induced protein prost-translational modification | x-ray diffraction | A | — | — |
| 4CRZ | Direct visualisation of strain-induced protein prost-translational modification | x-ray diffraction | A | — | — |
| 4CS0 | Direct visualisation of strain-induced protein post-translational modification | x-ray diffraction | A | — | — |
| 4CS0 | Direct visualisation of strain-induced protein post-translational modification | x-ray diffraction | A | — | — |
| 4D7Z | E. coli L-aspartate-alpha-decarboxylase mutant N72Q to a resolution of 1.9 Angstroms | x-ray diffraction | A, B | — | — |
| 4D7Z | E. COLI L-aspartate-alpha-decarboxylase mutant N72Q to a resolution of 1.9 ångströms | x-ray diffraction | A, B | — | — |
| 5LS7 | Complex of wild type E. coli alpha aspartate decarboxylase with its processing factor PanZ | x-ray diffraction | A, D | ACO, SCN, 74C, CO2 | 1 (best 0.61) |
| 5LS7 | Complex of wild type E. COLI alpha aspartate decarboxylase with its processing factor panz | x-ray diffraction | A, D | PVO, ACO, SCN, 74C, CO2 | — |
| P0A790 | AlphaFold monomer V2.0 prediction for aspartate 1-decarboxylase (P0A790) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4CRZ chain A against the predicted model P0A790: TM-score 0.99, RMSD 0.25 Å
- 4CRZ chain A against the predicted model P0A790: TM-score 0.99, RMSD 0.25 Å
- 1PT1 chain B against the predicted model P0A790: TM-score 1.00, RMSD 0.25 Å
- 1PT1 chain B against the predicted model P0A790: TM-score 1.00, RMSD 0.25 Å
- 5LS7 chain D against the predicted model P0A790: TM-score 1.00, RMSD 0.26 Å
- 1AW8 chain B against the predicted model P0A790: TM-score 0.99, RMSD 0.25 Å
- 1AW8 chain B against the predicted model P0A790: TM-score 0.99, RMSD 0.26 Å
- 4CRY chain G against the predicted model P0A790: TM-score 0.99, RMSD 0.27 Å
- 4CRY chain G against the predicted model P0A790: TM-score 0.99, RMSD 0.27 Å
- 5LS7 chain D against the predicted model P0A790: TM-score 0.99, RMSD 0.28 Å
Elsewhere
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