UniProt P0A6W9
Glutamate--cysteine ligase (P0A6W9)
Glutamate--cysteine ligase (UniProt P0A6W9), EC 6.3.2.2: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A6W9
- Protein
- Glutamate--cysteine ligase
- EC
- 6.3.2.2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 25 · 2 records with a druggable one
Structures
9 records of P0A6W9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1V4G | Crystal Structure of gamma-Glutamylcysteine Synthetase from Escherichia coli B | x-ray diffraction | A, B, C, D | — | 19 (best 0.83) |
| 1V4G | Crystal structure of gamma-glutamylcysteine synthetase from escherichia COLI B | x-ray diffraction | A, B, C, D | — | — |
| 1VA6 | Crystal structure of Gamma-glutamylcysteine synthetase from Escherichia Coli B complexed with… | x-ray diffraction | A, B | MG, P2S, ADP | 6 (best 0.86) |
| 1VA6 | Crystal structure of gamma-glutamylcysteine synthetase from escherichia COLI B complexed with… | x-ray diffraction | A, B | — | — |
| 2D32 | Crystal Structure of Michaelis Complex of gamma-Glutamylcysteine Synthetase | x-ray diffraction | A, B, C, D | — | — |
| 2D32 | Crystal structure of michaelis complex of gamma-glutamylcysteine synthetase | x-ray diffraction | A, B, C, D | — | — |
| 2D33 | Crystal Structure of gamma-Glutamylcysteine Synthetase Complexed with Aluminum Fluoride | x-ray diffraction | A, B, C, D | — | — |
| 2D33 | Crystal structure of gamma-glutamylcysteine synthetase complexed with aluminum fluoride | x-ray diffraction | A, B, C, D | — | — |
| P0A6W9 | AlphaFold monomer V2.0 prediction for glutamate--cysteine ligase (P0A6W9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1V4G chain B against the predicted model P0A6W9: TM-score 1.00, RMSD 0.43 Å
- 1V4G chain B against the predicted model P0A6W9: TM-score 1.00, RMSD 0.43 Å
- 1VA6 chain B against the predicted model P0A6W9: TM-score 0.99, RMSD 0.60 Å
- 1VA6 chain B against the predicted model P0A6W9: TM-score 0.99, RMSD 0.60 Å
- 1VA6 chain A against the predicted model P0A6W9: TM-score 0.99, RMSD 0.61 Å
- 1VA6 chain A against the predicted model P0A6W9: TM-score 0.99, RMSD 0.61 Å
- 2D32 chain B against the predicted model P0A6W9: TM-score 0.99, RMSD 0.36 Å
- 2D32 chain B against the predicted model P0A6W9: TM-score 0.99, RMSD 0.36 Å
- 2D32 chain C against the predicted model P0A6W9: TM-score 0.99, RMSD 0.36 Å
- 2D32 chain C against the predicted model P0A6W9: TM-score 0.99, RMSD 0.36 Å
Elsewhere
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