UniProt P0A4X7
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (P0A4X7)
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (UniProt P0A4X7), EC 2.6.1.62: 5 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites, druggability and experiment…
- UniProt
- P0A4X7
- Protein
- Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
- EC
- 2.6.1.62
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 2 records with a druggable one
Structures
6 records of P0A4X7 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KGS | Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis… | x-ray diffraction | A, B | PLP, 6SR | 5 (best 0.76) |
| 5KGS | Crystal structure of 7,8-diaminopelargonic acid synthase (bioa) from mycobacterium tuberculosis… | x-ray diffraction | A, B | PLP, 6SR | — |
| 5KGT | Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis… | x-ray diffraction | A, B | PLP, 6SQ | 5 (best 0.76) |
| 5KGT | Crystal structure of 7,8-diaminopelargonic acid synthase (bioa) from mycobacterium tuberculosis… | x-ray diffraction | A, B | PLP, 6SQ | — |
| 5TE2 | Crystal structure of 7,8-diaminopelargonic acid synthase (bioa) from mycobacterium tuberculosis… | x-ray diffraction | B, A | 7B9 | — |
| P0A4X7 | AlphaFold monomer V2.0 prediction for adenosylmethionine-8-amino-7-oxononanoate aminotransferase… | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 4 records
- 6SQ · 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone · in 2 records
- 6SR · 5-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]-2,3-dihydroinden-1-one · in 2 records
- 7B9 · [5-hydroxy-4-({[6-(3-hydroxypropyl)-4-oxo-1,4-dihydropyridin-3-yl]amino}methyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate · in 1 record
Experiment against prediction
- 5TE2 chain A against the predicted model P0A4X7: TM-score 0.99, RMSD 0.70 Å
- 5KGT chain A against the predicted model P0A4X7: TM-score 0.99, RMSD 0.86 Å
- 5KGT chain A against the predicted model P0A4X7: TM-score 0.99, RMSD 0.86 Å
- 5KGS chain B against the predicted model P0A4X7: TM-score 0.99, RMSD 0.86 Å
- 5KGS chain B against the predicted model P0A4X7: TM-score 0.99, RMSD 0.86 Å
- 5TE2 chain B against the predicted model P0A4X7: TM-score 0.99, RMSD 0.86 Å
- 5KGS chain A against the predicted model P0A4X7: TM-score 0.99, RMSD 0.87 Å
- 5KGS chain A against the predicted model P0A4X7: TM-score 0.99, RMSD 0.87 Å
- 5KGT chain B against the predicted model P0A4X7: TM-score 0.99, RMSD 0.90 Å
- 5KGT chain B against the predicted model P0A4X7: TM-score 0.99, RMSD 0.90 Å
Elsewhere
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