UniProt P09936
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UniProt P09936), EC 3.4.19.12: 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 30 pockets. Binding sites, druggability and experiment against…
- UniProt
- P09936
- Protein
- Ubiquitin carboxyl-terminal hydrolase isozyme L1
- EC
- 3.4.19.12
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 30 · 3 records with a druggable one
Structures
20 records of P09936 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ETL | Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) | x-ray diffraction | A, B | — | — |
| 2ETL | Crystal structure of ubiquitin carboxy-terminal hydrolase L1 (uch-L1) | x-ray diffraction | A, B | — | — |
| 2LEN | Solution structure of UCHL1 S18Y variant | solution nmr | A | — | — |
| 2LEN | Solution structure of UCHL1 S18Y variant | solution nmr | A | — | — |
| 3IFW | Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin… | x-ray diffraction | A | — | — |
| 3IFW | Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin… | x-ray diffraction | A | — | — |
| 3IRT | Crystal Structure of the I93M Mutant of Ubiquitin Carboxy-terminal Hydrolase L1 | x-ray diffraction | A, B | — | — |
| 3IRT | Crystal structure of the I93M mutant of ubiquitin carboxy-terminal hydrolase L1 | x-ray diffraction | A, B | — | — |
| 3KVF | Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin… | x-ray diffraction | A | — | — |
| 3KVF | Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin… | x-ray diffraction | A | — | — |
| 3KW5 | Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester | x-ray diffraction | A | — | — |
| 3KW5 | Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester | x-ray diffraction | A | — | — |
| 4DM9 | The Crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide… | x-ray diffraction | A, B | — | — |
| 4DM9 | The crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide… | x-ray diffraction | A, B | — | — |
| 4JKJ | Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 | x-ray diffraction | A, B | — | — |
| 4JKJ | Crystal structure of the S18Y variant of ubiquitin carboxy-terminal hydrolase L1 | x-ray diffraction | A, B | — | — |
| 7ZM0 | Structure of UCHL1 in complex with GK13S inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | JMF | 20 (best 0.79) |
| 8EDE | Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazid… | x-ray diffraction | A, B | WEU, SO4 | 4 (best 0.63) |
| 8XI7 | The Crystal Structure of UCHL1 from Biortus. | x-ray diffraction | A, B | SO4 | 5 (best 0.66) |
| P09936 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase isozyme L1 (P09936) | predicted | A | — | 1 (best 0.48) |
Ligands
Experiment against prediction
- 7ZM0 chain D against the predicted model P09936: TM-score 0.98, RMSD 0.61 Å
- 7ZM0 chain C against the predicted model P09936: TM-score 0.98, RMSD 0.73 Å
- 7ZM0 chain I against the predicted model P09936: TM-score 0.98, RMSD 0.67 Å
- 7ZM0 chain E against the predicted model P09936: TM-score 0.98, RMSD 0.77 Å
- 7ZM0 chain G against the predicted model P09936: TM-score 0.98, RMSD 0.67 Å
- 7ZM0 chain F against the predicted model P09936: TM-score 0.98, RMSD 0.68 Å
- 3IFW chain A against the predicted model P09936: TM-score 0.98, RMSD 0.99 Å
- 3IFW chain A against the predicted model P09936: TM-score 0.98, RMSD 0.99 Å
- 7ZM0 chain A against the predicted model P09936: TM-score 0.98, RMSD 0.60 Å
- 7ZM0 chain H against the predicted model P09936: TM-score 0.97, RMSD 0.78 Å
Elsewhere
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