UniProt P09884
DNA polymerase alpha catalytic subunit (P09884)
DNA polymerase alpha catalytic subunit (UniProt P09884), EC 2.7.7.7: 27 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P09884
- Protein
- DNA polymerase alpha catalytic subunit
- EC
- 2.7.7.7
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 52 · 4 records with a druggable one
Structures
28 records of P09884 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K0P | NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha | solution nmr | A | — | — |
| 1K0P | NMR structures of the zinc finger domain of human DNA polymerase-alpha | solution nmr | A | — | — |
| 1K18 | Minimized Average NMR Structure of the Zinc Finger Domain of Human DNA Polymerase-alpha | solution nmr | A | — | — |
| 1K18 | Minimized average NMR structure of the zinc finger domain of human DNA polymerase-alpha | solution nmr | A | — | — |
| 1N5G | NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha | solution nmr | A | — | — |
| 1N5G | NMR structures of the zinc finger domain of human DNA polymerase-alpha | solution nmr | A | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | B, D | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | B, D | — | — |
| 4Q5V | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an… | x-ray diffraction | A, E | — | — |
| 4Q5V | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an… | x-ray diffraction | A, E | — | — |
| 4QCL | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an… | x-ray diffraction | A | — | — |
| 4QCL | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an… | x-ray diffraction | A | — | — |
| 4Y97 | Crystal Structure of human Pol alpha B-subunit in complex with C-terminal domain of catalytic… | x-ray diffraction | B, D, F, H | — | — |
| 4Y97 | Crystal structure of human pol alpha B-subunit in complex with C- terminal domain of catalytic… | x-ray diffraction | B, D, F, H | — | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | C, G | ZN | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | C, G | — | — |
| 5IUD | Human DNA polymerase alpha in binary complex with a DNA:DNA template- primer | x-ray diffraction | A, D, G, J | — | — |
| 6AS7 | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an… | x-ray diffraction | A | DCP, MG | — |
| 7N2M | Crystal structure of DNA polymerase alpha catalytic core in complex with dctp and TEMPLATE/PRIMER… | x-ray diffraction | A | DCP, MG, ZN, K, SO4 | — |
| 7OPL | Cryoem structure of DNA polymerase alpha - primase bound to SARS cov NSP1 | electron microscopy | A | ZN | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | C | ZN | 10 (best 0.82) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | C | ZN | — |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | F | — | — |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | F | — | — |
| 8D9D | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | electron microscopy | C | MG, ZN, DTP | 11 (best 0.81) |
| 8QJ7 | Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 | electron microscopy | A | ZN | 16 (best 0.86) |
| 9C8V | Human DNA polymerase alpha/primase - CHAPSO (4 mM) | electron microscopy | C | ZN | 15 (best 0.87) |
| P09884 | AlphaFold monomer V2.0 prediction for DNA polymerase alpha catalytic subunit (P09884) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4Q5V chain A against the predicted model P09884: TM-score 0.99, RMSD 0.71 Å
- 4Q5V chain A against the predicted model P09884: TM-score 0.99, RMSD 0.71 Å
- 4Q5V chain E against the predicted model P09884: TM-score 0.99, RMSD 0.77 Å
- 4Q5V chain E against the predicted model P09884: TM-score 0.99, RMSD 0.77 Å
- 5IUD chain D against the predicted model P09884: TM-score 0.99, RMSD 0.94 Å
- 5IUD chain G against the predicted model P09884: TM-score 0.99, RMSD 1.01 Å
- 5IUD chain A against the predicted model P09884: TM-score 0.99, RMSD 1.06 Å
- 5IUD chain J against the predicted model P09884: TM-score 0.99, RMSD 1.17 Å
- 7N2M chain A against the predicted model P09884: TM-score 0.98, RMSD 1.72 Å
- 4QCL chain A against the predicted model P09884: TM-score 0.98, RMSD 1.74 Å
Elsewhere
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